Abstract
The thalamus plays a key role in filtering or gating information and has extensive interconnectivity with other brain regions. Recent studies provide evidence of thalamus abnormality in schizophrenia, but the resting functional networks of the thalamus in schizophrenia is still unclear. We characterize the thalamic resting-state networks (RSNs) in 72 patients with schizophrenia and 73 healthy controls, using a standard seedbased whole-brain correlation. In comparison with controls, patients exhibited enhance thalamic connectivity with bilateral precentral gyrus, dorsal medial frontal gyrus, middle occipital gyrus, and lingual gyrus. Reduced thalamic connectivity in schizophrenia was found in bilateral superior frontal gyrus, anterior cingualte cortex, inferior parietal lobe, and cerebellum. Our findings question the “disconnectivity model” of schizophrenia by showing the over-connected thalamic network during resting state in schizophrenia and highlight the thalamus as a key hub in the schizophrenic network abnormality.
| Original language | English |
|---|---|
| Journal | Frontiers in Behavioral Neuroscience |
| Volume | 9 |
| Issue number | FEB |
| DOIs | |
| Publication status | Published - 2015 Feb 25 |
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Keywords
- fMRI
- Functional connectivity
- Resting-state
- Schizophrenia
- Thalamus
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Cognitive Neuroscience
- Behavioral Neuroscience
Cite this
Disrupted thalamic resting-state functional networks in schizophrenia. / Wang, Hsiao Lan Sharon; Rau, Chi Lun; Li, Yu Mei; Chen, Ya Ping; Yu, Rongjun.
In: Frontiers in Behavioral Neuroscience, Vol. 9, No. FEB, 25.02.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Disrupted thalamic resting-state functional networks in schizophrenia
AU - Wang, Hsiao Lan Sharon
AU - Rau, Chi Lun
AU - Li, Yu Mei
AU - Chen, Ya Ping
AU - Yu, Rongjun
PY - 2015/2/25
Y1 - 2015/2/25
N2 - The thalamus plays a key role in filtering or gating information and has extensive interconnectivity with other brain regions. Recent studies provide evidence of thalamus abnormality in schizophrenia, but the resting functional networks of the thalamus in schizophrenia is still unclear. We characterize the thalamic resting-state networks (RSNs) in 72 patients with schizophrenia and 73 healthy controls, using a standard seedbased whole-brain correlation. In comparison with controls, patients exhibited enhance thalamic connectivity with bilateral precentral gyrus, dorsal medial frontal gyrus, middle occipital gyrus, and lingual gyrus. Reduced thalamic connectivity in schizophrenia was found in bilateral superior frontal gyrus, anterior cingualte cortex, inferior parietal lobe, and cerebellum. Our findings question the “disconnectivity model” of schizophrenia by showing the over-connected thalamic network during resting state in schizophrenia and highlight the thalamus as a key hub in the schizophrenic network abnormality.
AB - The thalamus plays a key role in filtering or gating information and has extensive interconnectivity with other brain regions. Recent studies provide evidence of thalamus abnormality in schizophrenia, but the resting functional networks of the thalamus in schizophrenia is still unclear. We characterize the thalamic resting-state networks (RSNs) in 72 patients with schizophrenia and 73 healthy controls, using a standard seedbased whole-brain correlation. In comparison with controls, patients exhibited enhance thalamic connectivity with bilateral precentral gyrus, dorsal medial frontal gyrus, middle occipital gyrus, and lingual gyrus. Reduced thalamic connectivity in schizophrenia was found in bilateral superior frontal gyrus, anterior cingualte cortex, inferior parietal lobe, and cerebellum. Our findings question the “disconnectivity model” of schizophrenia by showing the over-connected thalamic network during resting state in schizophrenia and highlight the thalamus as a key hub in the schizophrenic network abnormality.
KW - fMRI
KW - Functional connectivity
KW - Resting-state
KW - Schizophrenia
KW - Thalamus
UR - http://www.scopus.com/inward/record.url?scp=84925064067&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925064067&partnerID=8YFLogxK
U2 - 10.3389/fnbeh.2015.00045
DO - 10.3389/fnbeh.2015.00045
M3 - Article
AN - SCOPUS:84925064067
VL - 9
JO - Frontiers in Behavioral Neuroscience
JF - Frontiers in Behavioral Neuroscience
SN - 1662-5153
IS - FEB
ER -