Discriminating Hepatocellular Carcinoma in Rats Using a High-Tc SQUID Detected Nuclear Resonance Spectrometer in a Magnetic Shielding Box

Kai Wen Huang, Hsin Hsien Chen, Hong Chang Yang, Herng Er Horng, Shu Hsien Liao, Shieh Yueh Yang, Jen Jie Chieh, Li Ming Wang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this study, we report the spin-lattice relaxation rate of hepatocellular carcinoma (HCC) and normal liver tissue in rats using a high-Tc superconducting quantum interference device (SQUID) based nuclear magnetic resonance (NMR) spectrometer. The resonance spectrometer used for discriminating liver tumors in rats via the difference in longitudinal relaxation time in low magnetic fields was set up in a compact and portable magnetic shielding box. The frequency-domain NMR signals of HCC tissues and normal liver tissues were analyzed to study their respective longitudinal relaxation rate T1-1. The T1-1 of liver tissues for ten normal rats and ten cancerous rats were investigated respectively. The averaged T1-1 value of normal liver tissue was (6.41±0.66) s-1, and the averaged T1-1 value of cancerous tissue was (3.38±0.15) s-1. The ratio of T1-1 for normal liver tissues and cancerous liver tissues of the rats investigated is estimated to be 1.9. Since this significant statistical difference, the T1-1 value can be used to distinguish the HCC tissues from normal liver tissues. This method of examining liver and tumor tissues has the advantages of being convenient, easy to operate, and stable.

Original languageEnglish
Article numbere47057
JournalPloS one
Volume7
Issue number10
DOIs
Publication statusPublished - 2012 Oct 5

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Magnetic shielding
SQUIDs
hepatoma
spectrometers
Spectrometers
Rats
Hepatocellular Carcinoma
Liver
Tissue
Equipment and Supplies
rats
liver
nuclear magnetic resonance spectroscopy
Tumors
tissues
Magnetic Resonance Spectroscopy
Magnetic resonance spectrometers
Nuclear magnetic resonance
Spin-lattice relaxation
liver neoplasms

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Discriminating Hepatocellular Carcinoma in Rats Using a High-Tc SQUID Detected Nuclear Resonance Spectrometer in a Magnetic Shielding Box. / Huang, Kai Wen; Chen, Hsin Hsien; Yang, Hong Chang; Horng, Herng Er; Liao, Shu Hsien; Yang, Shieh Yueh; Chieh, Jen Jie; Wang, Li Ming.

In: PloS one, Vol. 7, No. 10, e47057, 05.10.2012.

Research output: Contribution to journalArticle

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