TY - JOUR
T1 - Directly labeling ferrite nanoparticles with Tc-99m radioisotope for diagnostic applications
AU - Fu, Chao Ming
AU - Wang, Yuh Feng
AU - Chao, Yu Chiang
AU - Hung, Shih Hung
AU - Yang, Ming Da
N1 - Funding Information:
Manuscript received October 15, 2003. This work was supported in part by the Taiwan National Science Foundation under Grant NSC-91-2112-M-017-004 and Grant NSC-93-2112-M-017-001. C.-M. Fu, Y.-C. Chao, S.-H. Hung, and M.-D. Yang are with the Physics Department, National Kaoshiung Normal University, Kaoshiung, Taiwan, R.O.C. (e-mail: [email protected]). Y.-F. Wang is with the Department of Nuclear Medicine, Buddhish Dalin TzuChi General Hospital, Taiwan, R.O.C. Digital Object Identifier 10.1109/TMAG.2004.834199
PY - 2004/7
Y1 - 2004/7
N2 - We report a novel approach of directly labeling the radioisotope Tc99m with magnetite (Fe3O4) nanoparticles for diagnostic applications. The magnetite nanoparticles were first synthesized from aqueous solutions of Fe(II) and Fe(III) chloride, with addition of ammonium hydroxide. Subsequently, the radioisotope Tc-99m were mixed directly into the reaction solution with ferrite precipitation. The labeling efficiency, of ferrite nanoparticles bound with Tc-99m, is above 99%. As prepared radioactive ferrite nanoparticles were intravenously injected into rats. The biodistribution of radioactivity, monitored by gamma-camera, has shown the uptake of radiomicrospheres can be restrained and transferable in vivo in the living animals by applying an external Nd-Fe-B magnet. Final fate of the radiomicrospheres is to be related with the surface charge of particles. Modification of surface charge of the radiolabeled ferrite nanobeads for clinical targeted diagnosis is discussed.
AB - We report a novel approach of directly labeling the radioisotope Tc99m with magnetite (Fe3O4) nanoparticles for diagnostic applications. The magnetite nanoparticles were first synthesized from aqueous solutions of Fe(II) and Fe(III) chloride, with addition of ammonium hydroxide. Subsequently, the radioisotope Tc-99m were mixed directly into the reaction solution with ferrite precipitation. The labeling efficiency, of ferrite nanoparticles bound with Tc-99m, is above 99%. As prepared radioactive ferrite nanoparticles were intravenously injected into rats. The biodistribution of radioactivity, monitored by gamma-camera, has shown the uptake of radiomicrospheres can be restrained and transferable in vivo in the living animals by applying an external Nd-Fe-B magnet. Final fate of the radiomicrospheres is to be related with the surface charge of particles. Modification of surface charge of the radiolabeled ferrite nanobeads for clinical targeted diagnosis is discussed.
KW - Ferrite
KW - Nanoparticles
KW - Radioisotope
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U2 - 10.1109/TMAG.2004.834199
DO - 10.1109/TMAG.2004.834199
M3 - Article
AN - SCOPUS:4444359941
SN - 0018-9464
VL - 40
SP - 3003
EP - 3005
JO - IEEE Transactions on Magnetics
JF - IEEE Transactions on Magnetics
IS - 4 II
ER -