DIRECT RENAL EFFECTS OF ENDOTHELIN IN CHRONIC HYPOXIC SPONTANEOUSLY HYPERTENSIVE RATS

C. F. Chen; C. T. Chien; M. S. Wu

doi:10.1111/j.1440-1681.1992.tb00419.x

DIRECT RENAL EFFECTS OF ENDOTHELIN IN CHRONIC HYPOXIC SPONTANEOUSLY HYPERTENSIVE RATS

C. F. Chen^*, C. T. Chien, M. S. Wu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

1. The direct renal effects of endothelin (ET) were studied in eight chronic hypoxic rats (HA) and eight sea level (SL) spontaneously hypertensive rats (SHR). 2. After 4 weeks of exposure to simulated 5486 m (18000 ft) hypoxia, all HA rats were in apparently good health, and baseline renal function, except effective renal blood flow, was not significantly different from SL rats. 3. Intrarenal arterial administration of ET (600 ng/ kg per h) reduced ipsilateral renal excretion of water, sodium and potassium, glomerular filtration rate and effective renal plasma flow in both SL and HA rats to almost the same extent. 4. Administration of ET antiserum, however, increased the renal excretion of water in HA rats. 5. It is concluded that ET may play a role in the renal regulation of chronic hypoxic SHR.

Original language	English
Pages (from-to)	809-813
Number of pages	5
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	19
Issue number	12
DOIs	https://doi.org/10.1111/j.1440-1681.1992.tb00419.x
Publication status	Published - 1992 Dec
Externally published	Yes

Keywords

chronic hypoxia
endothelin
renal function
spontaneously hypertensive rats

ASJC Scopus subject areas

Physiology
Pharmacology
Physiology (medical)

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10.1111/j.1440-1681.1992.tb00419.x

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title = "DIRECT RENAL EFFECTS OF ENDOTHELIN IN CHRONIC HYPOXIC SPONTANEOUSLY HYPERTENSIVE RATS",

abstract = "1. The direct renal effects of endothelin (ET) were studied in eight chronic hypoxic rats (HA) and eight sea level (SL) spontaneously hypertensive rats (SHR). 2. After 4 weeks of exposure to simulated 5486 m (18000 ft) hypoxia, all HA rats were in apparently good health, and baseline renal function, except effective renal blood flow, was not significantly different from SL rats. 3. Intrarenal arterial administration of ET (600 ng/ kg per h) reduced ipsilateral renal excretion of water, sodium and potassium, glomerular filtration rate and effective renal plasma flow in both SL and HA rats to almost the same extent. 4. Administration of ET antiserum, however, increased the renal excretion of water in HA rats. 5. It is concluded that ET may play a role in the renal regulation of chronic hypoxic SHR.",

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AU - Chen, C. F.

AU - Chien, C. T.

AU - Wu, M. S.

PY - 1992/12

Y1 - 1992/12

N2 - 1. The direct renal effects of endothelin (ET) were studied in eight chronic hypoxic rats (HA) and eight sea level (SL) spontaneously hypertensive rats (SHR). 2. After 4 weeks of exposure to simulated 5486 m (18000 ft) hypoxia, all HA rats were in apparently good health, and baseline renal function, except effective renal blood flow, was not significantly different from SL rats. 3. Intrarenal arterial administration of ET (600 ng/ kg per h) reduced ipsilateral renal excretion of water, sodium and potassium, glomerular filtration rate and effective renal plasma flow in both SL and HA rats to almost the same extent. 4. Administration of ET antiserum, however, increased the renal excretion of water in HA rats. 5. It is concluded that ET may play a role in the renal regulation of chronic hypoxic SHR.

AB - 1. The direct renal effects of endothelin (ET) were studied in eight chronic hypoxic rats (HA) and eight sea level (SL) spontaneously hypertensive rats (SHR). 2. After 4 weeks of exposure to simulated 5486 m (18000 ft) hypoxia, all HA rats were in apparently good health, and baseline renal function, except effective renal blood flow, was not significantly different from SL rats. 3. Intrarenal arterial administration of ET (600 ng/ kg per h) reduced ipsilateral renal excretion of water, sodium and potassium, glomerular filtration rate and effective renal plasma flow in both SL and HA rats to almost the same extent. 4. Administration of ET antiserum, however, increased the renal excretion of water in HA rats. 5. It is concluded that ET may play a role in the renal regulation of chronic hypoxic SHR.

KW - chronic hypoxia

KW - endothelin

KW - renal function

KW - spontaneously hypertensive rats

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ER -

DIRECT RENAL EFFECTS OF ENDOTHELIN IN CHRONIC HYPOXIC SPONTANEOUSLY HYPERTENSIVE RATS

Abstract

Keywords

ASJC Scopus subject areas

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