Direct β-acylation of 2-arylidene-1,3-indandiones with acyl chlorides catalyzed by organophosphanes

Chia Jui Lee; Chia Ning Sheu; Cheng Che Tsai; Zong Ze Wu; Wenwei Lin

doi:10.1039/c3cc45201h

Direct β-acylation of 2-arylidene-1,3-indandiones with acyl chlorides catalyzed by organophosphanes

Chia Jui Lee, Chia Ning Sheu, Cheng Che Tsai, Zong Ze Wu, Wenwei Lin^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

We have developed an organophosphane-catalyzed direct β-acylation of a series of conjugated systems bearing ketone, amide and ester functionalities using acyl chlorides as trapping reagents. A wide variety of highly functional ketone derivatives were generated efficiently under very mild conditions with high yields according to our protocol. Our adducts can even be utilized as important building blocks for the synthesis of functional tri/tetracyclic pyridazine derivatives.

Original language	English
Pages (from-to)	5304-5306
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	40
DOIs	https://doi.org/10.1039/c3cc45201h
Publication status	Published - 2014 Apr 22

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c3cc45201h

Cite this

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title = "Direct β-acylation of 2-arylidene-1,3-indandiones with acyl chlorides catalyzed by organophosphanes",

abstract = "We have developed an organophosphane-catalyzed direct β-acylation of a series of conjugated systems bearing ketone, amide and ester functionalities using acyl chlorides as trapping reagents. A wide variety of highly functional ketone derivatives were generated efficiently under very mild conditions with high yields according to our protocol. Our adducts can even be utilized as important building blocks for the synthesis of functional tri/tetracyclic pyridazine derivatives.",

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AU - Lee, Chia Jui

AU - Sheu, Chia Ning

AU - Tsai, Cheng Che

AU - Wu, Zong Ze

AU - Lin, Wenwei

PY - 2014/4/22

Y1 - 2014/4/22

N2 - We have developed an organophosphane-catalyzed direct β-acylation of a series of conjugated systems bearing ketone, amide and ester functionalities using acyl chlorides as trapping reagents. A wide variety of highly functional ketone derivatives were generated efficiently under very mild conditions with high yields according to our protocol. Our adducts can even be utilized as important building blocks for the synthesis of functional tri/tetracyclic pyridazine derivatives.

AB - We have developed an organophosphane-catalyzed direct β-acylation of a series of conjugated systems bearing ketone, amide and ester functionalities using acyl chlorides as trapping reagents. A wide variety of highly functional ketone derivatives were generated efficiently under very mild conditions with high yields according to our protocol. Our adducts can even be utilized as important building blocks for the synthesis of functional tri/tetracyclic pyridazine derivatives.

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ER -

Direct β-acylation of 2-arylidene-1,3-indandiones with acyl chlorides catalyzed by organophosphanes

Abstract

ASJC Scopus subject areas

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CCDC 937197: Experimental Crystal Structure Determination

CCDC 935874: Experimental Crystal Structure Determination

CCDC 935872: Experimental Crystal Structure Determination

Cite this

Direct β-acylation of 2-arylidene-1,3-indandiones with acyl chlorides catalyzed by organophosphanes

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Datasets

CCDC 937197: Experimental Crystal Structure Determination

CCDC 935874: Experimental Crystal Structure Determination

CCDC 935872: Experimental Crystal Structure Determination

Cite this