Dietary Monascus adlay supplements facilitate suppression of cigarette smoke-induced pulmonary endoplasmic reticulum stress, autophagy, apoptosis and emphysema-related PLGF in the rat

Ping Chia Li, Wen Hsin Tsai, Chiang Ting Chien

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Cigarette smoke (CS) exposure may cause oxidative stress in the lung, leading to cell death and long-term injury. Monascus adlay (MA) with antioxidant components produced by inoculating adlay (Cois lachrymal-jobi L. var. ma-yuen Stapf) with Monascus purpureus may protect lung against CS-induced lung injuries in rats. MA and lovastatin had higher antioxidant activities than either M. purpureus or adlay. CS exposure caused significant lung damage, as evidenced by higher levels of reactive oxygen species (ROS), neutrophil infiltration, dityrosine and 4-HNE, as well as lower levels of Mn-superoxide dismutase and catalase expression. Lung tissues with CS exposure had higher levels of ER stress, apoptosis, autophagy and emphysema-related placenta growth factor (PlGF) expressions. All CS-induced injuries were significantly suppressed by MA supplements. MA would be a beneficial nutritional therapy to ameliorate CS-induced lung injury via preserving antioxidant defense mechanisms, decreasing oxidative stress and inhibiting ER stress, autophagy, apoptosis and emphysema-related risk factor.

Original languageEnglish
Pages (from-to)765-774
Number of pages10
JournalFood Chemistry
Volume136
Issue number2
DOIs
Publication statusPublished - 2013 Jan 15

Fingerprint

Monascus
Coix lacryma-jobi
Endoplasmic Reticulum Stress
autophagy
cigarettes
Autophagy
Emphysema
smoke
Smoke
Tobacco Products
endoplasmic reticulum
Rats
apoptosis
lungs
Apoptosis
Lung
rats
Monascus purpureus
Oxidative stress
Antioxidants

Keywords

  • Acute lung injury
  • Apoptosis
  • Autophagy
  • Cigarette smoke
  • Endoplasmic reticulum stress
  • Oxidative stress

ASJC Scopus subject areas

  • Analytical Chemistry
  • Food Science

Cite this

@article{c37f28578b2a4930bac9473b6260262d,
title = "Dietary Monascus adlay supplements facilitate suppression of cigarette smoke-induced pulmonary endoplasmic reticulum stress, autophagy, apoptosis and emphysema-related PLGF in the rat",
abstract = "Cigarette smoke (CS) exposure may cause oxidative stress in the lung, leading to cell death and long-term injury. Monascus adlay (MA) with antioxidant components produced by inoculating adlay (Cois lachrymal-jobi L. var. ma-yuen Stapf) with Monascus purpureus may protect lung against CS-induced lung injuries in rats. MA and lovastatin had higher antioxidant activities than either M. purpureus or adlay. CS exposure caused significant lung damage, as evidenced by higher levels of reactive oxygen species (ROS), neutrophil infiltration, dityrosine and 4-HNE, as well as lower levels of Mn-superoxide dismutase and catalase expression. Lung tissues with CS exposure had higher levels of ER stress, apoptosis, autophagy and emphysema-related placenta growth factor (PlGF) expressions. All CS-induced injuries were significantly suppressed by MA supplements. MA would be a beneficial nutritional therapy to ameliorate CS-induced lung injury via preserving antioxidant defense mechanisms, decreasing oxidative stress and inhibiting ER stress, autophagy, apoptosis and emphysema-related risk factor.",
keywords = "Acute lung injury, Apoptosis, Autophagy, Cigarette smoke, Endoplasmic reticulum stress, Oxidative stress",
author = "Li, {Ping Chia} and Tsai, {Wen Hsin} and Chien, {Chiang Ting}",
year = "2013",
month = "1",
day = "15",
doi = "10.1016/j.foodchem.2012.08.007",
language = "English",
volume = "136",
pages = "765--774",
journal = "Food Chemistry",
issn = "0308-8146",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Dietary Monascus adlay supplements facilitate suppression of cigarette smoke-induced pulmonary endoplasmic reticulum stress, autophagy, apoptosis and emphysema-related PLGF in the rat

AU - Li, Ping Chia

AU - Tsai, Wen Hsin

AU - Chien, Chiang Ting

PY - 2013/1/15

Y1 - 2013/1/15

N2 - Cigarette smoke (CS) exposure may cause oxidative stress in the lung, leading to cell death and long-term injury. Monascus adlay (MA) with antioxidant components produced by inoculating adlay (Cois lachrymal-jobi L. var. ma-yuen Stapf) with Monascus purpureus may protect lung against CS-induced lung injuries in rats. MA and lovastatin had higher antioxidant activities than either M. purpureus or adlay. CS exposure caused significant lung damage, as evidenced by higher levels of reactive oxygen species (ROS), neutrophil infiltration, dityrosine and 4-HNE, as well as lower levels of Mn-superoxide dismutase and catalase expression. Lung tissues with CS exposure had higher levels of ER stress, apoptosis, autophagy and emphysema-related placenta growth factor (PlGF) expressions. All CS-induced injuries were significantly suppressed by MA supplements. MA would be a beneficial nutritional therapy to ameliorate CS-induced lung injury via preserving antioxidant defense mechanisms, decreasing oxidative stress and inhibiting ER stress, autophagy, apoptosis and emphysema-related risk factor.

AB - Cigarette smoke (CS) exposure may cause oxidative stress in the lung, leading to cell death and long-term injury. Monascus adlay (MA) with antioxidant components produced by inoculating adlay (Cois lachrymal-jobi L. var. ma-yuen Stapf) with Monascus purpureus may protect lung against CS-induced lung injuries in rats. MA and lovastatin had higher antioxidant activities than either M. purpureus or adlay. CS exposure caused significant lung damage, as evidenced by higher levels of reactive oxygen species (ROS), neutrophil infiltration, dityrosine and 4-HNE, as well as lower levels of Mn-superoxide dismutase and catalase expression. Lung tissues with CS exposure had higher levels of ER stress, apoptosis, autophagy and emphysema-related placenta growth factor (PlGF) expressions. All CS-induced injuries were significantly suppressed by MA supplements. MA would be a beneficial nutritional therapy to ameliorate CS-induced lung injury via preserving antioxidant defense mechanisms, decreasing oxidative stress and inhibiting ER stress, autophagy, apoptosis and emphysema-related risk factor.

KW - Acute lung injury

KW - Apoptosis

KW - Autophagy

KW - Cigarette smoke

KW - Endoplasmic reticulum stress

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=84866843836&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866843836&partnerID=8YFLogxK

U2 - 10.1016/j.foodchem.2012.08.007

DO - 10.1016/j.foodchem.2012.08.007

M3 - Article

C2 - 23122125

AN - SCOPUS:84866843836

VL - 136

SP - 765

EP - 774

JO - Food Chemistry

JF - Food Chemistry

SN - 0308-8146

IS - 2

ER -