Abstract
Reaction of chiral α,β-unsaturated carboxylic acid derivatives 2a-e derived from camphor pyrazolidinone 1 with thiols affords β-mercaptocarboxylic acid derivatives 3a-e with a wide range of stereoselectivities (up to > 90% de). The stereoselectivity as a function of Lewis acid is described. The auxiliary can be easily recovered from the Michael adducts under mild conditions. (C) 2000 Elsevier Science Ltd.
Original language | English |
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Pages (from-to) | 6815-6819 |
Number of pages | 5 |
Journal | Tetrahedron Letters |
Volume | 41 |
Issue number | 35 |
DOIs | |
Publication status | Published - 2000 Aug 26 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry