Formula presented Reaction of chiral acryloylhydrazide 5 derived from novel auxiliary 4 with aldehydes in the presence of DABCO affords practical levels (up to 98% de) of β-hydroxy-α-methylene carbonyl derivatives, and high optical purity of both diastereomers of 6a-d and 7a-d can be obtained by changing the solvent.
|Number of pages||3|
|Publication status||Published - 2000 Mar 23|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry