Diastereoselective Baylis-Hillman reactions: The design and synthesis of a novel camphor-Based chiral auxiliary

Kung Shuo Yang, Kwunmin Chen

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Formula presented Reaction of chiral acryloylhydrazide 5 derived from novel auxiliary 4 with aldehydes in the presence of DABCO affords practical levels (up to 98% de) of β-hydroxy-α-methylene carbonyl derivatives, and high optical purity of both diastereomers of 6a-d and 7a-d can be obtained by changing the solvent.

Original languageEnglish
Pages (from-to)729-731
Number of pages3
JournalOrganic Letters
Volume2
Issue number6
Publication statusPublished - 2000 Mar 23

Fingerprint

Camphor
camphor
aldehydes
methylene
Aldehydes
purity
Derivatives
synthesis
triethylenediamine

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Diastereoselective Baylis-Hillman reactions : The design and synthesis of a novel camphor-Based chiral auxiliary. / Yang, Kung Shuo; Chen, Kwunmin.

In: Organic Letters, Vol. 2, No. 6, 23.03.2000, p. 729-731.

Research output: Contribution to journalArticle

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