Abstract
The camphorpyrazolidinone derived N-glyoxylate was efficiently prepared and used as an electrophile in the Baylis-Hillman reaction under classical DABCO catalyzed conditions. The corresponding 2-hydroxy-3-methylene succinic acid derivative was generally obtained with excellent diastereoselectivity and moderate chemical yields (51-75%).
Original language | English |
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Pages (from-to) | 2541-2543 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 45 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2004 Mar 15 |
Keywords
- Diasteroselective Baylis-Hillman
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry