Diastereoselective [3+2] cycloadditions of a camphor-derived chiral N- acryloylhydrazide with nitrile oxides: The preparation of optically pure δ2-isoxazolines

Kung Shuo Yang, Jung Chaing Lain, Chun Hui Lin, Kwunmin Chen

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Reaction of a novel chiral N-acryloylhydrazide with various nitrile oxides proceeded smoothly to afford the cycloadduct with high diastereoselectivity (99:1). The auxiliary can be easily removed from the cycloadducts under mild conditions. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)1453-1456
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number9
DOIs
Publication statusPublished - 2000 Feb 26

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Camphor
Nitriles
Cycloaddition
Cycloaddition Reaction
Oxides

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Diastereoselective [3+2] cycloadditions of a camphor-derived chiral N- acryloylhydrazide with nitrile oxides : The preparation of optically pure δ2-isoxazolines. / Yang, Kung Shuo; Lain, Jung Chaing; Lin, Chun Hui; Chen, Kwunmin.

In: Tetrahedron Letters, Vol. 41, No. 9, 26.02.2000, p. 1453-1456.

Research output: Contribution to journalArticle

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