Diagnosis and prognosis of myocardial infarction on a plasmonic chip

Wei Xu, Lin Wang, Ru Zhang, Xuming Sun, Lin Huang, Haiyang Su, Xunbin Wei, Chia Chun Chen, Jiatao Lou, Hongjie Dai, Kun Qian

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    Cardiovascular diseases lead to 31.5% of deaths globally, and particularly myocardial infarction (MI) results in 7.4 million deaths per year. Diagnosis of MI and monitoring for prognostic use are critical for clinical management and biomedical research, which require advanced tools with accuracy and speed. Herein, we developed a plasmonic gold nano-island (pGold) chip assay for diagnosis and monitoring of MI. On-chip microarray analysis of serum biomarkers (e.g., cardiac troponin I) afforded up to 130-fold enhancement of near-infrared fluorescence for ultra-sensitive and quantitative detection within controlled periods, using 10 μL of serum only. The pGold chip assay achieved MI diagnostic sensitivity of 100% and specificity of 95.54%, superior to the standard chemiluminescence immunoassay in cardiovascular clinics. Further, we monitored biomarker concentrations regarding percutaneous coronary intervention for prognostic purpose. Our work demonstrated a designed approach using plasmonic materials for enhanced diagnosis and monitoring for prognostic use towards point-of-care testing.

    Original languageEnglish
    Pages (from-to)1654
    Number of pages1
    JournalNature Communications
    Volume11
    Issue number1
    DOIs
    Publication statusPublished - 2020 Apr 3

    ASJC Scopus subject areas

    • Chemistry(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Physics and Astronomy(all)

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