Development of an on-line microextraction method for use in fiber-spray/mass spectrometry

Yea Wenn Liou, Jian Siang Wang, Chien Chung Chen, Cheng Huang Lin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


A novel fiber-spray/mass spectrometry method using a piece of a porous hollow fiber is described. An adapter, fabricated by a 3D-printer, was designed to connect the fiber and a standard ESI (electrospray ionization) needle, in which a Taylor cone was formed and the resulting ions were detected by a mass spectrometer. Since a porous hollow fiber is usually used for microextraction, the so-called hollow fiber liquid-phase microextraction (HF-LPME) method, a new methodology that involves coupling HF-LPME and fiber-spray, was developed for the first time. We report herein on the design and testing of a microextraction kit. The kit consists of a centrifuge tube (reservoir for the sample solution) and a piece of a porous hollow fiber (for sample extraction). The kit was placed between the mass inlet and the ESI needle. Using the kit, analytes can be extracted from a very dilute solution and then evaporate and escape from the fiber surface. When they make contact with the ESI plume, which arises from the ESI needle tip, the molecules are ionized and then detected by a mass spectrometer. Using the setup, it was possible to improve the limit of detection after microextraction by ∼360-fold when 3,4-MDMA (3,4-methylenedioxymethamphetamine) was analyzed, and the limit of detection achieved was 2 ng/mL.

Original languageEnglish
Pages (from-to)178-183
Number of pages6
JournalInternational Journal of Mass Spectrometry
Publication statusPublished - 2017 Oct


  • 3,4-Methylenedioxymethamphetamine
  • Fiber-spray/mass spectrometry
  • Hollow fiber liquid phase microextraction

ASJC Scopus subject areas

  • Instrumentation
  • Condensed Matter Physics
  • Spectroscopy
  • Physical and Theoretical Chemistry


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