Determination of lysergic acid diethylamide (LSD) by application of online 77 K fluorescence spectroscopy and a sweeping technique in micellar electrokinetic chromatography

Ching Fang, Ju Tsung Liu, Cheng Huang Lin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The principal advantage of the use of Shopl'skii effect (low temperature spectrum) is that spectral sharpening occurs both in absorption and emission. However, thus far using the technique of capillary electrophoresis/low temperature fluorescence spectroscopy (CE/LTFS) either at 77 or 4.2 K remains difficult to obtain an on-line spectrum, if the analyte is present at low concentration. This paper examines the feasibility of combining the techniques of online concentration and CE/LTFS to identify LSD and related compounds in urine at 77 K. To improve sensitivity, sweeping-micellar electrokinetic chromatography (sweeping-MEKC) and cation-selective exhaustive injection-sweep-micellar electro-kinetic chromatography (CSEI-sweep-MEKC) were used for on-line concentration which resulted in detection limits of ∼ 20 ∼ 60 ppt, respectively.

Original languageEnglish
Pages (from-to)691-699
Number of pages9
JournalTalanta
Volume58
Issue number4
DOIs
Publication statusPublished - 2002 Oct 16

Keywords

  • Capillary electrophoresis
  • Iso-lysergic acid diethylamide (iso-LSD)
  • Low temperature fluorescence spectroscopy
  • Lysergic acid N,N-methylpropylamide (LAMPA)
  • Lysergic acid diethylamide (LSD)
  • Sweeping

ASJC Scopus subject areas

  • Analytical Chemistry

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