Detection of electrical characteristics of DNA strands immobilized on self-assembled multilayer gold nanoparticles

Chien Ying Tsai; Tien Li Chang; Long Sheng Kuo; Ping Hei Chen

doi:10.1063/1.2390653

Detection of electrical characteristics of DNA strands immobilized on self-assembled multilayer gold nanoparticles

Chien Ying Tsai^*, Tien Li Chang, Long Sheng Kuo, Ping Hei Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Electric detection of DNA in biosensors can be achieved by comparing the differences between the electrical characteristics of biosensors with various concentrations of DNA. This study shows significant electrical property differences between single-stranded DNA and double-stranded DNA by immobilizing DNA strands on biosensor's self-assembled multilayer gold nanoparticles. The double-stranded DNA has lower electrical resistance than that of single-stranded DNA. These differences can be possibly utilized for DNA identification.

Original language	English
Article number	203902
Journal	Applied Physics Letters
Volume	89
Issue number	20
DOIs	https://doi.org/10.1063/1.2390653
Publication status	Published - 2006
Externally published	Yes

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.2390653

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title = "Detection of electrical characteristics of DNA strands immobilized on self-assembled multilayer gold nanoparticles",

abstract = "Electric detection of DNA in biosensors can be achieved by comparing the differences between the electrical characteristics of biosensors with various concentrations of DNA. This study shows significant electrical property differences between single-stranded DNA and double-stranded DNA by immobilizing DNA strands on biosensor's self-assembled multilayer gold nanoparticles. The double-stranded DNA has lower electrical resistance than that of single-stranded DNA. These differences can be possibly utilized for DNA identification.",

author = "Tsai, {Chien Ying} and Chang, {Tien Li} and Kuo, {Long Sheng} and Chen, {Ping Hei}",

note = "Funding Information: The authors wish to thank National Nano Device Laboratories under Contract No. NDL-94S-C117 for providing experimental facilities for this research. They also deeply appreciate the financial support of the National Science Council of Taiwan, Republic of China under Contract No. NSC 94-2212-E-002-049.",

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AU - Tsai, Chien Ying

AU - Chang, Tien Li

AU - Kuo, Long Sheng

AU - Chen, Ping Hei

N1 - Funding Information: The authors wish to thank National Nano Device Laboratories under Contract No. NDL-94S-C117 for providing experimental facilities for this research. They also deeply appreciate the financial support of the National Science Council of Taiwan, Republic of China under Contract No. NSC 94-2212-E-002-049.

PY - 2006

Y1 - 2006

N2 - Electric detection of DNA in biosensors can be achieved by comparing the differences between the electrical characteristics of biosensors with various concentrations of DNA. This study shows significant electrical property differences between single-stranded DNA and double-stranded DNA by immobilizing DNA strands on biosensor's self-assembled multilayer gold nanoparticles. The double-stranded DNA has lower electrical resistance than that of single-stranded DNA. These differences can be possibly utilized for DNA identification.

AB - Electric detection of DNA in biosensors can be achieved by comparing the differences between the electrical characteristics of biosensors with various concentrations of DNA. This study shows significant electrical property differences between single-stranded DNA and double-stranded DNA by immobilizing DNA strands on biosensor's self-assembled multilayer gold nanoparticles. The double-stranded DNA has lower electrical resistance than that of single-stranded DNA. These differences can be possibly utilized for DNA identification.

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Detection of electrical characteristics of DNA strands immobilized on self-assembled multilayer gold nanoparticles

Abstract

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