Detection of electrical characteristics of DNA strands immobilized on self-assembled multilayer gold nanoparticles

Chien Ying Tsai, Tien Li Chang, Long Sheng Kuo, Ping Hei Chen

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Abstract

Electric detection of DNA in biosensors can be achieved by comparing the differences between the electrical characteristics of biosensors with various concentrations of DNA. This study shows significant electrical property differences between single-stranded DNA and double-stranded DNA by immobilizing DNA strands on biosensor's self-assembled multilayer gold nanoparticles. The double-stranded DNA has lower electrical resistance than that of single-stranded DNA. These differences can be possibly utilized for DNA identification.

Original languageEnglish
Article number203902
JournalApplied Physics Letters
Volume89
Issue number20
DOIs
Publication statusPublished - 2006 Nov 23
Externally publishedYes

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ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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