Design and synthesis of 1-(beta-D-ribofuranosyl)imidazo[4,5-c]pyrazoles as 5: 5 bicyclic analogs of purine nucleosides.

Tun Cheng Chien, John C. Drach, Leroy B. Townsend

Research output: Contribution to journalArticle

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Abstract

5-Alkylaminopyrazole nucleosides underwent nitrosation to give the corresponding N1-ribosylated 5-alkyl-amino-4-nitrosopyrazoles. The intramolecular cyclo-dehydration reactions of these 5-alkylamino-4-nitrosopyrazoles were carried out in pyridine at reflux temperature to afford the ring-closure N-1 ribosylated imidazo[4,5-c]pyrazoles in good yields.

Original languageEnglish
Pages (from-to)593-594
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number52
Publication statusPublished - 2008 Dec 1

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Nitrosation
Purine Nucleosides
Dehydration
Nucleosides
Temperature
imidazo(4,5-c)pyrazole
pyridine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Design and synthesis of 1-(beta-D-ribofuranosyl)imidazo[4,5-c]pyrazoles as 5 : 5 bicyclic analogs of purine nucleosides. / Chien, Tun Cheng; Drach, John C.; Townsend, Leroy B.

In: Nucleic acids symposium series (2004), No. 52, 01.12.2008, p. 593-594.

Research output: Contribution to journalArticle

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