Design and synthesis of 1-(beta-D-ribofuranosyl)imidazo[4,5-c]pyrazoles as 5:5 bicyclic analogs of purine nucleosides.

Tun Cheng Chien, John C. Drach, Leroy B. Townsend

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

5-Alkylaminopyrazole nucleosides underwent nitrosation to give the corresponding N1-ribosylated 5-alkyl-amino-4-nitrosopyrazoles. The intramolecular cyclo-dehydration reactions of these 5-alkylamino-4-nitrosopyrazoles were carried out in pyridine at reflux temperature to afford the ring-closure N-1 ribosylated imidazo[4,5-c]pyrazoles in good yields.

Original languageEnglish
Pages (from-to)593-594
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number52
Publication statusPublished - 2008

ASJC Scopus subject areas

  • Medicine(all)

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