Design and construction of paper-spray ionization/mass spectrometry

Cheng Huang Lin, Yea Wenn Liou

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter discusses general aspects of paper spray ionization that is used in mass spectrometry (MS). The methodology and theory are associated with a number of different related applications. The first part of this chapter discusses the fundamentals of paper spray and some modifications, such as tissue spray, are also included. The second part focuses on recent applications, including the analysis of biologically important molecules. These studies show that paper spray MS has great potential for use as a rapid sampling ionization method and for the direct analysis of biological and chemical samples at ambient conditions.

Original languageEnglish
Title of host publicationAmbient Ionization Mass Spectrometry in Life Sciences
Subtitle of host publicationPrinciples and Applications
Number of pages33
ISBN (Electronic)9780128172209
Publication statusPublished - 2019 Jan 1


  • Chromatography paper
  • Dried blood spots
  • Electrospray ionization
  • Mass spectrometry
  • Paper spray

ASJC Scopus subject areas

  • General Chemistry


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