Depression by a green tea extract of alcohol-induced oxidative stress and lipogenesis in rat liver

Kuo Hsin Chen, Ping Chia Li, Wei Hsiang Lin, Chiang Ting Chien*, Boon Hua Low

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


We determined the effects of a green tea extract with 36% alcohol on the blood alcohol content, oxidative stress, lipogenesis, inflammation and liver function of female Wistar rats. Tea alcohol significantly decreased the O 2 -, H 2O 2 and HOCl amounts via catechins and not caffeine. Thirty days of alcohol gavage improved the level of reactive oxygen species (ROS) in the liver, bile and blood, increased the 4-hydroxynonenal-protein adducts, Kupffer cell infiltration and lipid accumulation in the liver, and elevated the plasma alanine aminotransferase level. A western blot analysis showed reduced expression of the oxidative enzymes (CYP2E1 and NADPH oxidase p47phox protein) and lipogenic enzymes (SREBP-1c and fatty acid synthase) in the alcohol-treated liver. Tea alcohol significantly attenuated these elevated parameters. We conclude that the green tea extract in alcohol efficiently reduced the amounts of O 2 -, H 2O 2 and HOCl primarily due to the catechin content, and not caffeine. The developed tea liquor attenuated alcohol-induced oxidative injury and lipogenesis in the liver by the synergetic action of catechins and caffeine.

Original languageEnglish
Pages (from-to)1668-1676
Number of pages9
JournalBioscience, Biotechnology and Biochemistry
Issue number9
Publication statusPublished - 2011
Externally publishedYes


  • Alcohol
  • Caffeine
  • Catechin
  • Lipogenesis
  • Oxidative stress

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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