Cumulative Risks of Developing Extrapyramidal Signs, Psychosis, or Myoclonus in the Course of Alzheimer's Disease

Jenn Yeu Chen, Yaakov Stern, Mary Sano, Richard Mayeux

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Cumulative risks of developing extrapyramidal signs, psychosis, and myoclonus in the course of Alzheimer's disease (AD) were estimated in 72 patients with probable AD by the Kaplan-Meier survival method. The cumulative risk functions were found to increase at different rates for different signs as AD progressed. Comparisons of the cumulative risk functions revealed that in the early stages of AD, extrapyramidal signs and psychosis were more likely to develop than myoclonus. As AD progressed, the risk of developing myoclonus became as great as that of developing the other two signs. This study suggests that extrapyramidal signs, psychosis, and myoclonus represent developmental features that mark the progression of AD, rather than indicators of disease subtypes. The estimated cumulative risk functions set a reasonable expectation for the timing and likelihood of the emergence of the clinical signs. This, in turn, might aid in disease prognosis because the biological bases of these signs have been established and they have been shown to be predictive of other markers of disease course.

Original languageEnglish
Pages (from-to)1141-1143
Number of pages3
JournalArchives of Neurology
Volume48
Issue number11
DOIs
Publication statusPublished - 1991 Nov

Fingerprint

Myoclonus
Psychotic Disorders
Alzheimer Disease
Alzheimer's Disease
Psychosis
Survival

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Cumulative Risks of Developing Extrapyramidal Signs, Psychosis, or Myoclonus in the Course of Alzheimer's Disease. / Chen, Jenn Yeu; Stern, Yaakov; Sano, Mary; Mayeux, Richard.

In: Archives of Neurology, Vol. 48, No. 11, 11.1991, p. 1141-1143.

Research output: Contribution to journalArticle

@article{4eb377bbf78d49ebb912bff5aa048b56,
title = "Cumulative Risks of Developing Extrapyramidal Signs, Psychosis, or Myoclonus in the Course of Alzheimer's Disease",
abstract = "Cumulative risks of developing extrapyramidal signs, psychosis, and myoclonus in the course of Alzheimer's disease (AD) were estimated in 72 patients with probable AD by the Kaplan-Meier survival method. The cumulative risk functions were found to increase at different rates for different signs as AD progressed. Comparisons of the cumulative risk functions revealed that in the early stages of AD, extrapyramidal signs and psychosis were more likely to develop than myoclonus. As AD progressed, the risk of developing myoclonus became as great as that of developing the other two signs. This study suggests that extrapyramidal signs, psychosis, and myoclonus represent developmental features that mark the progression of AD, rather than indicators of disease subtypes. The estimated cumulative risk functions set a reasonable expectation for the timing and likelihood of the emergence of the clinical signs. This, in turn, might aid in disease prognosis because the biological bases of these signs have been established and they have been shown to be predictive of other markers of disease course.",
author = "Chen, {Jenn Yeu} and Yaakov Stern and Mary Sano and Richard Mayeux",
year = "1991",
month = "11",
doi = "10.1001/archneur.1991.00530230049020",
language = "English",
volume = "48",
pages = "1141--1143",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "11",

}

TY - JOUR

T1 - Cumulative Risks of Developing Extrapyramidal Signs, Psychosis, or Myoclonus in the Course of Alzheimer's Disease

AU - Chen, Jenn Yeu

AU - Stern, Yaakov

AU - Sano, Mary

AU - Mayeux, Richard

PY - 1991/11

Y1 - 1991/11

N2 - Cumulative risks of developing extrapyramidal signs, psychosis, and myoclonus in the course of Alzheimer's disease (AD) were estimated in 72 patients with probable AD by the Kaplan-Meier survival method. The cumulative risk functions were found to increase at different rates for different signs as AD progressed. Comparisons of the cumulative risk functions revealed that in the early stages of AD, extrapyramidal signs and psychosis were more likely to develop than myoclonus. As AD progressed, the risk of developing myoclonus became as great as that of developing the other two signs. This study suggests that extrapyramidal signs, psychosis, and myoclonus represent developmental features that mark the progression of AD, rather than indicators of disease subtypes. The estimated cumulative risk functions set a reasonable expectation for the timing and likelihood of the emergence of the clinical signs. This, in turn, might aid in disease prognosis because the biological bases of these signs have been established and they have been shown to be predictive of other markers of disease course.

AB - Cumulative risks of developing extrapyramidal signs, psychosis, and myoclonus in the course of Alzheimer's disease (AD) were estimated in 72 patients with probable AD by the Kaplan-Meier survival method. The cumulative risk functions were found to increase at different rates for different signs as AD progressed. Comparisons of the cumulative risk functions revealed that in the early stages of AD, extrapyramidal signs and psychosis were more likely to develop than myoclonus. As AD progressed, the risk of developing myoclonus became as great as that of developing the other two signs. This study suggests that extrapyramidal signs, psychosis, and myoclonus represent developmental features that mark the progression of AD, rather than indicators of disease subtypes. The estimated cumulative risk functions set a reasonable expectation for the timing and likelihood of the emergence of the clinical signs. This, in turn, might aid in disease prognosis because the biological bases of these signs have been established and they have been shown to be predictive of other markers of disease course.

UR - http://www.scopus.com/inward/record.url?scp=0025836705&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025836705&partnerID=8YFLogxK

U2 - 10.1001/archneur.1991.00530230049020

DO - 10.1001/archneur.1991.00530230049020

M3 - Article

C2 - 1953398

AN - SCOPUS:0025836705

VL - 48

SP - 1141

EP - 1143

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 11

ER -