Cord plasma concentrations of adiponectin and leptin in healthy term neonates: Positive correlation with birthweight and neonatal adiposity

Po Jung Tsai, Chun Hsien Yu*, Shih Penn Hsu, Yu Hsiang Lee, Chuen Hua Chiou, Yu Wen Hsu, Su Chen Ho, Chun Hong Chu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

172 Citations (Scopus)


OBJECTIVE: Adiponectin is negatively associated with leptin, insulin and obesity in children and adults. Whereas increases in fetal insulin and leptin are associated with increased weight and adiposity at birth, the role of adiponectin in fetal growth has not yet been determined. The aims of this study were to examine the relationships between adiponectin and insulin, leptin, weight and adiposity at birth in healthy term infants. DESIGN AND METHODS: Anthropometric parameters including weight, length, circumferences and skinfold thickness were measured, and plasma lipid profiles, insulin, leptin and adiponectin concentrations in cord blood samples from 226 singleton infants born at term after uncomplicated pregnancies were assayed. RESULTS: Cord plasma adiponectin, leptin and insulin levels correlated significantly and positively with birthweight (P = 0.001, P < 0.001, P < 0.001, respectively) and the sum of skinfold thicknesses (P < 0.001, P < 0.001, P < 0.001, respectively). Mean cord plasma adiponectin and leptin levels, but not insulin level, were significantly higher in large-for-gestational-age (LGA) infants compared with appropriate-for-gestational-age (AGA) infants. Cord plasma leptin concentration, but not adiponectin concentration, was significantly higher in female infants than in male infants (P = 0.003 and P = 0.94, respectively). Cord plasma adiponectin concentration correlated positively with leptin level (P = 0.007) but not with insulin level (P = 0.78). CONCLUSIONS: High adiponectin levels are present in the cord blood. Cord plasma adiponectin and leptin levels are positively correlated with birthweight and adiposity. This suggests that adiponectin may be involved in regulating fetal growth.

Original languageEnglish
Pages (from-to)88-93
Number of pages6
JournalClinical Endocrinology
Issue number1
Publication statusPublished - 2004 Jul
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


Dive into the research topics of 'Cord plasma concentrations of adiponectin and leptin in healthy term neonates: Positive correlation with birthweight and neonatal adiposity'. Together they form a unique fingerprint.

Cite this