@article{5af9364f180143d2915ec81a9c226452,
title = "Copper(i) iodide-catalyzed synthesis of N,N′-disubstituted guanidines from n-substituted cyanamides",
abstract = "A facile and effective synthesis of N-alkyl-N′-arylguanidines was accomplished by the reaction of N-arylcyanamides with various primary and secondary alkylamines, under the catalysis of copper(i) iodide and Xantphos in DMF. This methodology provides a direct access to versatile N,N′- disubstituted guanidine derivatives from N-arylcyanamides that can be readily prepared from the corresponding nitriles via Tiemann rearrangement.",
author = "Zeng, {Cian Jhe} and Chen, {Chia Jung} and Chang, {Chih Wei} and Chen, {Hui Ting} and Chien, {Tun Cheng}",
note = "Funding Information: This work was supported by Research Grants 102–2113-M-003–004-and 102–2113-M-037–003-from Ministry of Science and Technology, Taiwan, and NTNU100-D-06 from National Taiwan Normal University. We also thank Professor Choon Hong Tan (Nanyang Technological University) for his helpful discussion and Mr Ting-Shen Kuo (National Taiwan Normal University) for his assistance with X-ray crystallographic analysis.",
year = "2014",
doi = "10.1071/CH14197",
language = "English",
volume = "67",
pages = "1134--1137",
journal = "Australian Journal of Chemistry",
issn = "0004-9425",
publisher = "CSIRO",
number = "7",
}