Copper(i) iodide-catalyzed synthesis of N,N′-disubstituted guanidines from n-substituted cyanamides

Cian Jhe Zeng, Chia Jung Chen, Chih Wei Chang, Hui Ting Chen, Tun Cheng Chien

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7 Citations (Scopus)


A facile and effective synthesis of N-alkyl-N′-arylguanidines was accomplished by the reaction of N-arylcyanamides with various primary and secondary alkylamines, under the catalysis of copper(i) iodide and Xantphos in DMF. This methodology provides a direct access to versatile N,N′- disubstituted guanidine derivatives from N-arylcyanamides that can be readily prepared from the corresponding nitriles via Tiemann rearrangement.

Original languageEnglish
Pages (from-to)1134-1137
Number of pages4
JournalAustralian Journal of Chemistry
Issue number7
Publication statusPublished - 2014


ASJC Scopus subject areas

  • Chemistry(all)

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