Copper nanoparticle and nitrogen doped graphite oxide based biosensor for the sensitive determination of glucose

Kulandaivel Sivasankar, Karuppasamy Kohila Rani, Sea Fue Wang*, Rajkumar Devasenathipathy, Chia Her Lin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Copper nanoparticles with the diameter of 50 ± 20 nm decorated nitrogen doped graphite oxide (NGO) have been prepared through a simple single step carbonization method using copper metal-organic framework (MOF), [Cu2 (BDC)2 (DABCO)] (where BDC is 1,4-benzenedicarboxylate, and DABCO is 1,4-Diazabicyclo[2.2.2]octane) as precursor. The surface morphology, porosity, surface area and elemental composition of CuNPs/NGO were characterized by various techniques. The as-synthesized CuNPs/NGO nanomaterials were coated on commercially available disposable screen-printed carbon electrode for the sensitive determination of glucose. We find that the modified electrode can detect glucose between 1 µM and 1803 µM (linear range) with good sensitivity (2500 µA mM−1 cm−2). Our glucose sensor also possesses low limits of detection (0.44 µM) towards glucose determination. The highly selective nature of the fabricated electrode was clearly visible from the selectivity studies. The practicability of CuNPs/NGO modified electrode has been validated in the human serum samples. The storage stability along with better repeatability and reproducibility results additionally substantiate the superior electrocatalytic activity of our constructed sensor towards glucose.

Original languageEnglish
Article number429
Issue number6
Publication statusPublished - 2018 Jun 12
Externally publishedYes


  • Amperometric techniques
  • Copper nanoparticles
  • Glucose
  • Human serum samples
  • Metal-organic framework
  • Nitrogen doped graphite oxide

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Science(all)


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