TY - JOUR
T1 - Copper nanoparticle and nitrogen doped graphite oxide based biosensor for the sensitive determination of glucose
AU - Sivasankar, Kulandaivel
AU - Rani, Karuppasamy Kohila
AU - Wang, Sea Fue
AU - Devasenathipathy, Rajkumar
AU - Lin, Chia Her
N1 - Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2018/6/12
Y1 - 2018/6/12
N2 - Copper nanoparticles with the diameter of 50 ± 20 nm decorated nitrogen doped graphite oxide (NGO) have been prepared through a simple single step carbonization method using copper metal-organic framework (MOF), [Cu2 (BDC)2 (DABCO)] (where BDC is 1,4-benzenedicarboxylate, and DABCO is 1,4-Diazabicyclo[2.2.2]octane) as precursor. The surface morphology, porosity, surface area and elemental composition of CuNPs/NGO were characterized by various techniques. The as-synthesized CuNPs/NGO nanomaterials were coated on commercially available disposable screen-printed carbon electrode for the sensitive determination of glucose. We find that the modified electrode can detect glucose between 1 µM and 1803 µM (linear range) with good sensitivity (2500 µA mM−1 cm−2). Our glucose sensor also possesses low limits of detection (0.44 µM) towards glucose determination. The highly selective nature of the fabricated electrode was clearly visible from the selectivity studies. The practicability of CuNPs/NGO modified electrode has been validated in the human serum samples. The storage stability along with better repeatability and reproducibility results additionally substantiate the superior electrocatalytic activity of our constructed sensor towards glucose.
AB - Copper nanoparticles with the diameter of 50 ± 20 nm decorated nitrogen doped graphite oxide (NGO) have been prepared through a simple single step carbonization method using copper metal-organic framework (MOF), [Cu2 (BDC)2 (DABCO)] (where BDC is 1,4-benzenedicarboxylate, and DABCO is 1,4-Diazabicyclo[2.2.2]octane) as precursor. The surface morphology, porosity, surface area and elemental composition of CuNPs/NGO were characterized by various techniques. The as-synthesized CuNPs/NGO nanomaterials were coated on commercially available disposable screen-printed carbon electrode for the sensitive determination of glucose. We find that the modified electrode can detect glucose between 1 µM and 1803 µM (linear range) with good sensitivity (2500 µA mM−1 cm−2). Our glucose sensor also possesses low limits of detection (0.44 µM) towards glucose determination. The highly selective nature of the fabricated electrode was clearly visible from the selectivity studies. The practicability of CuNPs/NGO modified electrode has been validated in the human serum samples. The storage stability along with better repeatability and reproducibility results additionally substantiate the superior electrocatalytic activity of our constructed sensor towards glucose.
KW - Amperometric techniques
KW - Copper nanoparticles
KW - Glucose
KW - Human serum samples
KW - Metal-organic framework
KW - Nitrogen doped graphite oxide
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U2 - 10.3390/nano8060429
DO - 10.3390/nano8060429
M3 - Article
AN - SCOPUS:85048616223
SN - 2079-4991
VL - 8
JO - Nanomaterials
JF - Nanomaterials
IS - 6
M1 - 429
ER -