Copper-Catalyzed Dual Cyclization for the Synthesis of Quinindolines

Hung Kai Wang, Yu Lun Chio, Gangaram Pallikonda, Hsyueh Liang Wu*, Haw Lih Su, Jen Chieh Hsieh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


A synthetic approach to quinindoline derivatives by the Cu-catalyzed dual cyclization has been developed. This catalytic reaction is a practical method for the systematic synthesis of quinindoline core structure, which contains a limited-step synthetic strategy and can tolerant a wide variety of substituents. In addition, the mechanistic study reveals that the reaction initiates from a Lewis acid accelerated addition of aniline to nitrile and provides the indole substructure, and then the subsequent Cu-catalyzed C-N coupling reaction furnishes the quinoline subunit and affords the quinindoline structure.

Original languageEnglish
Article number5303
Issue number22
Publication statusPublished - 2020 Nov 1


  • N-heterocycle
  • copper-catalyzed
  • cyclization
  • natural alkaloid
  • quinindoline

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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