Construction of fused, bridged, and spiro bicyclic skeletons via nickel-catalyzed intramolecular cyclization of cyclic 1,3-dienes and a tethered aldehyde

Ming Chang P. Yeh, Jong Hao Liang, Yi Lin Jiang, Ming Shan Tsai

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Nickel-catalyzed intramolecular cyclization of cyclohexa-1,3-dienes and an aldehyde in a chain produced fused, bridged or spiro bicyclic skeletons depending on the length of the tether. This chemistry can be extended to cyclohepta-1,3-dienes and cyclohepta-1,3,5-trienes having an aldehyde moiety on the side chain.

Original languageEnglish
Pages (from-to)3409-3415
Number of pages7
JournalTetrahedron
Volume59
Issue number19
DOIs
Publication statusPublished - 2003 May 5

Keywords

  • Cyclic 1,3-dienes
  • Fused, bridged, and spiro carbobicycles
  • Nickel
  • Stereoselectivity

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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