Confocal mapping of myelin figures with micro-Raman spectroscopy

Jung Ren Huang*, Yu Che Cheng, Hung Ji Huang, Hai Pang Chiang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We employ confocal micro-Raman spectroscopy (CMRS) with submicron spatial resolution to study the myelin structures (cylindrical lamellae) composed of nested surfactant C12E3 or lipid DMPC bilayers. The CMRS mapping indicates that for a straight C12E3 myelin, the surfactant concentration increases with the myelin width and is higher in the center region than in the peripheral region. For a curved C12E3 myelin, the convex side has a higher surfactant concentration than the corresponding concave side. The spectrum of DMPC myelins undergoes a qualitative change as the temperature increases above 60 °C, suggesting that the surfactant molecules may be damaged. Our work demonstrates the utility of CMRS in bio-soft material research.

Original languageEnglish
Article number58
JournalApplied Physics A: Materials Science and Processing
Volume124
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)

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