Computer simulations of membrane protein folding: Structure and dynamics

Chi-Ming Chen, C. C. Chen

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A lattice model of membrane proteins with a composite energy function is proposed to study their folding dynamics and native structures using Monte Carlo simulations. This model successfully predicts the seven helix bundle structure of sensory rhodopsin I by practicing a three-stage folding. Folding dynamics of a transmembrane segment into a helix is further investigated by varying the cooperativity in the formation of a helices for both random folding and assisted folding. The chain length dependence of the folding time of a hydrophobic segment to a helical state is studied for both free and anchored chains. An unusual length dependence in the folding time of anchored chains is observed.

Original languageEnglish
Pages (from-to)1902-1908
Number of pages7
JournalBiophysical Journal
Volume84
Issue number3
DOIs
Publication statusPublished - 2003 Mar 1

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Protein Folding
Computer Simulation
Membrane Proteins
Sensory Rhodopsins

ASJC Scopus subject areas

  • Biophysics

Cite this

Computer simulations of membrane protein folding : Structure and dynamics. / Chen, Chi-Ming; Chen, C. C.

In: Biophysical Journal, Vol. 84, No. 3, 01.03.2003, p. 1902-1908.

Research output: Contribution to journalArticle

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