This study investigated the effectiveness of computer input devices on clients with spinal cord injury. Single-subject multiple probe design was used to compare the accuracy and speed of inputs of baseline and intervention phases. Three persons with spinal cord injury participated this study. The participants' levels of the lesion were cervical 3-4, cervical 4-5 and cervical 5-6. In the baseline phase, participants used the regular mouse to move the cursor and click the target. In the intervention phase, the researchers provided participants the computer input devices based on the results of individual assessment. Experimental results indicated that persons with spinal cord injury indeed improved the accuracy and the speed of computer inputs after the assistive equipment provided. Through appropriate input devices, clients with spinal cord injury are able to operate computer effectively.