Comparison of the use of aqueous and nonaqueous buffers in association with cyclodextrin for the chiral separation of 3,4-methylenedioxymethamphetamine and related compounds

Yu San Huang; Chung Chen Tsai; Ju Tsung Liu; Cheng Huang Lin

doi:10.1002/elps.200410374

Comparison of the use of aqueous and nonaqueous buffers in association with cyclodextrin for the chiral separation of 3,4-methylenedioxymethamphetamine and related compounds

Yu San Huang, Chung Chen Tsai, Ju Tsung Liu, Cheng Huang Lin^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A comparison of the use of aqueous and nonaqueous buffers in association with β-CD or the chiral separation of (R)- and (S)-3,4-methylenedioxymethamphetamine and related compounds is described. The (R)- and (S)-isomers of 3,4-methylenedioxymethamphetamine (MDMA) and its major metabolite 3,4-methylenedioxyamphetamine (MDA) were prepared. Under aqueous and nonaqueous buffer conditions and based on the CZE and MEKC modes, the order of migration of (R)-MDA, (S)-MDA, (R)-MDMA, and the (S)-MDMA enantioisomers were determined. Several electrophoretic parameters, including the concentration of β-CD (aqueous, 25-60 mM; nonaqueous, 20-150 mM) used in the electrophoretic separation and the amount of organic solvents required for the separation, were optimized.

Original language	English
Pages (from-to)	3904-3909
Number of pages	6
Journal	Electrophoresis
Volume	26
Issue number	20
DOIs	https://doi.org/10.1002/elps.200410374
Publication status	Published - 2005 Oct

Keywords

3,4-Methylenedioxymethamphetamine
Aqueous and nonaqueous buffers
Capillary electrophoresis
Enantioseparation

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Clinical Biochemistry

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10.1002/elps.200410374

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title = "Comparison of the use of aqueous and nonaqueous buffers in association with cyclodextrin for the chiral separation of 3,4-methylenedioxymethamphetamine and related compounds",

abstract = "A comparison of the use of aqueous and nonaqueous buffers in association with β-CD or the chiral separation of (R)- and (S)-3,4-methylenedioxymethamphetamine and related compounds is described. The (R)- and (S)-isomers of 3,4-methylenedioxymethamphetamine (MDMA) and its major metabolite 3,4-methylenedioxyamphetamine (MDA) were prepared. Under aqueous and nonaqueous buffer conditions and based on the CZE and MEKC modes, the order of migration of (R)-MDA, (S)-MDA, (R)-MDMA, and the (S)-MDMA enantioisomers were determined. Several electrophoretic parameters, including the concentration of β-CD (aqueous, 25-60 mM; nonaqueous, 20-150 mM) used in the electrophoretic separation and the amount of organic solvents required for the separation, were optimized.",

keywords = "3,4-Methylenedioxymethamphetamine, Aqueous and nonaqueous buffers, Capillary electrophoresis, Enantioseparation",

author = "Huang, {Yu San} and Tsai, {Chung Chen} and Liu, {Ju Tsung} and Lin, {Cheng Huang}",

year = "2005",

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AU - Tsai, Chung Chen

AU - Liu, Ju Tsung

AU - Lin, Cheng Huang

PY - 2005/10

Y1 - 2005/10

N2 - A comparison of the use of aqueous and nonaqueous buffers in association with β-CD or the chiral separation of (R)- and (S)-3,4-methylenedioxymethamphetamine and related compounds is described. The (R)- and (S)-isomers of 3,4-methylenedioxymethamphetamine (MDMA) and its major metabolite 3,4-methylenedioxyamphetamine (MDA) were prepared. Under aqueous and nonaqueous buffer conditions and based on the CZE and MEKC modes, the order of migration of (R)-MDA, (S)-MDA, (R)-MDMA, and the (S)-MDMA enantioisomers were determined. Several electrophoretic parameters, including the concentration of β-CD (aqueous, 25-60 mM; nonaqueous, 20-150 mM) used in the electrophoretic separation and the amount of organic solvents required for the separation, were optimized.

AB - A comparison of the use of aqueous and nonaqueous buffers in association with β-CD or the chiral separation of (R)- and (S)-3,4-methylenedioxymethamphetamine and related compounds is described. The (R)- and (S)-isomers of 3,4-methylenedioxymethamphetamine (MDMA) and its major metabolite 3,4-methylenedioxyamphetamine (MDA) were prepared. Under aqueous and nonaqueous buffer conditions and based on the CZE and MEKC modes, the order of migration of (R)-MDA, (S)-MDA, (R)-MDMA, and the (S)-MDMA enantioisomers were determined. Several electrophoretic parameters, including the concentration of β-CD (aqueous, 25-60 mM; nonaqueous, 20-150 mM) used in the electrophoretic separation and the amount of organic solvents required for the separation, were optimized.

KW - 3,4-Methylenedioxymethamphetamine

KW - Aqueous and nonaqueous buffers

KW - Capillary electrophoresis

KW - Enantioseparation

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JF - Electrophoresis

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Comparison of the use of aqueous and nonaqueous buffers in association with cyclodextrin for the chiral separation of 3,4-methylenedioxymethamphetamine and related compounds

Abstract

Keywords

ASJC Scopus subject areas

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