Comparison of the use of aqueous and nonaqueous buffers in association with cyclodextrin for the chiral separation of 3,4-methylenedioxymethamphetamine and related compounds

Yu San Huang, Chung Chen Tsai, Ju Tsung Liu, Cheng Huang Lin

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A comparison of the use of aqueous and nonaqueous buffers in association with β-CD or the chiral separation of (R)- and (S)-3,4-methylenedioxymethamphetamine and related compounds is described. The (R)- and (S)-isomers of 3,4-methylenedioxymethamphetamine (MDMA) and its major metabolite 3,4-methylenedioxyamphetamine (MDA) were prepared. Under aqueous and nonaqueous buffer conditions and based on the CZE and MEKC modes, the order of migration of (R)-MDA, (S)-MDA, (R)-MDMA, and the (S)-MDMA enantioisomers were determined. Several electrophoretic parameters, including the concentration of β-CD (aqueous, 25-60 mM; nonaqueous, 20-150 mM) used in the electrophoretic separation and the amount of organic solvents required for the separation, were optimized.

Original languageEnglish
Pages (from-to)3904-3909
Number of pages6
JournalElectrophoresis
Volume26
Issue number20
DOIs
Publication statusPublished - 2005 Oct 1

Fingerprint

N-Methyl-3,4-methylenedioxyamphetamine
Cyclodextrins
Buffers
3,4-Methylenedioxyamphetamine
Micellar Electrokinetic Capillary Chromatography
Metabolites
Isomers
Organic solvents

Keywords

  • 3,4-Methylenedioxymethamphetamine
  • Aqueous and nonaqueous buffers
  • Capillary electrophoresis
  • Enantioseparation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

Cite this

Comparison of the use of aqueous and nonaqueous buffers in association with cyclodextrin for the chiral separation of 3,4-methylenedioxymethamphetamine and related compounds. / Huang, Yu San; Tsai, Chung Chen; Liu, Ju Tsung; Lin, Cheng Huang.

In: Electrophoresis, Vol. 26, No. 20, 01.10.2005, p. 3904-3909.

Research output: Contribution to journalArticle

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