Comparison of the characteristic mass fragmentations of phenethylamines and tryptamines by electron ionization gas chromatography mass spectrometry, electrospray and matrix-assisted laser desorption ionization mass spectrometry

Bo Hong Chen, Ju Tsung Liu, Hung Ming Chen, Wen Xiong Chen, Cheng Huang Lin

Research output: Contribution to journalArticle

Abstract

Characteristic mass fragmentation of 20 phenethylamine/tryptamine standards were investigated and compared by means of matrix assisted laser desorption/time-of-flight mass spectrometry (MALDI/TOFM), gas chromatography-electron ionization-mass spectrometry (GC-EI/MS) and liquid chromatography-electrospray ionization/mass spectrometry (LC-ESI/MS) methods. As a result, three characteristic peaks ([M]+ and fragments from the Cβ-Cα bond breakage) were found to be unique and contained information useful in identifying 2C series compounds based on the GC-EI/MS method. We found that the protonated molecular ion ([M+H]+) and two types of fragments produced from the α-cleavage and β-cleavage processes were useful mass spectral information in the rapid screening and confirmation of phenethylamine and tryptamine derivatives when ESI/MS and MALDI/TOFMS methods were applied. This assay was successfully used to determine samples that contain illicit drugs.

Original languageEnglish
Article number1022
JournalApplied Sciences (Switzerland)
Volume8
Issue number7
DOIs
Publication statusPublished - 2018 Jun 22

Fingerprint

tryptamines
Tryptamines
Phenethylamines
gas chromatography
Gas chromatography
Ionization
Mass spectrometry
Desorption
fragmentation
mass spectroscopy
desorption
ionization
Electrons
Lasers
matrices
lasers
cleavage
fragments
Electrospray ionization
Liquid chromatography

Keywords

  • GC-EI/MS
  • LC-ESI/MS
  • MALDI/TOFMS
  • Phenethylamine
  • Tryptamine

ASJC Scopus subject areas

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

Cite this

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title = "Comparison of the characteristic mass fragmentations of phenethylamines and tryptamines by electron ionization gas chromatography mass spectrometry, electrospray and matrix-assisted laser desorption ionization mass spectrometry",
abstract = "Characteristic mass fragmentation of 20 phenethylamine/tryptamine standards were investigated and compared by means of matrix assisted laser desorption/time-of-flight mass spectrometry (MALDI/TOFM), gas chromatography-electron ionization-mass spectrometry (GC-EI/MS) and liquid chromatography-electrospray ionization/mass spectrometry (LC-ESI/MS) methods. As a result, three characteristic peaks ([M]+ and fragments from the Cβ-Cα bond breakage) were found to be unique and contained information useful in identifying 2C series compounds based on the GC-EI/MS method. We found that the protonated molecular ion ([M+H]+) and two types of fragments produced from the α-cleavage and β-cleavage processes were useful mass spectral information in the rapid screening and confirmation of phenethylamine and tryptamine derivatives when ESI/MS and MALDI/TOFMS methods were applied. This assay was successfully used to determine samples that contain illicit drugs.",
keywords = "GC-EI/MS, LC-ESI/MS, MALDI/TOFMS, Phenethylamine, Tryptamine",
author = "Chen, {Bo Hong} and Liu, {Ju Tsung} and Chen, {Hung Ming} and Chen, {Wen Xiong} and Lin, {Cheng Huang}",
year = "2018",
month = "6",
day = "22",
doi = "10.3390/app8071022",
language = "English",
volume = "8",
journal = "Applied Sciences (Switzerland)",
issn = "2076-3417",
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TY - JOUR

T1 - Comparison of the characteristic mass fragmentations of phenethylamines and tryptamines by electron ionization gas chromatography mass spectrometry, electrospray and matrix-assisted laser desorption ionization mass spectrometry

AU - Chen, Bo Hong

AU - Liu, Ju Tsung

AU - Chen, Hung Ming

AU - Chen, Wen Xiong

AU - Lin, Cheng Huang

PY - 2018/6/22

Y1 - 2018/6/22

N2 - Characteristic mass fragmentation of 20 phenethylamine/tryptamine standards were investigated and compared by means of matrix assisted laser desorption/time-of-flight mass spectrometry (MALDI/TOFM), gas chromatography-electron ionization-mass spectrometry (GC-EI/MS) and liquid chromatography-electrospray ionization/mass spectrometry (LC-ESI/MS) methods. As a result, three characteristic peaks ([M]+ and fragments from the Cβ-Cα bond breakage) were found to be unique and contained information useful in identifying 2C series compounds based on the GC-EI/MS method. We found that the protonated molecular ion ([M+H]+) and two types of fragments produced from the α-cleavage and β-cleavage processes were useful mass spectral information in the rapid screening and confirmation of phenethylamine and tryptamine derivatives when ESI/MS and MALDI/TOFMS methods were applied. This assay was successfully used to determine samples that contain illicit drugs.

AB - Characteristic mass fragmentation of 20 phenethylamine/tryptamine standards were investigated and compared by means of matrix assisted laser desorption/time-of-flight mass spectrometry (MALDI/TOFM), gas chromatography-electron ionization-mass spectrometry (GC-EI/MS) and liquid chromatography-electrospray ionization/mass spectrometry (LC-ESI/MS) methods. As a result, three characteristic peaks ([M]+ and fragments from the Cβ-Cα bond breakage) were found to be unique and contained information useful in identifying 2C series compounds based on the GC-EI/MS method. We found that the protonated molecular ion ([M+H]+) and two types of fragments produced from the α-cleavage and β-cleavage processes were useful mass spectral information in the rapid screening and confirmation of phenethylamine and tryptamine derivatives when ESI/MS and MALDI/TOFMS methods were applied. This assay was successfully used to determine samples that contain illicit drugs.

KW - GC-EI/MS

KW - LC-ESI/MS

KW - MALDI/TOFMS

KW - Phenethylamine

KW - Tryptamine

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