Cognitive control in opioid dependence and methadone maintenance treatment

Ding Lieh Liao, Cheng Yi Huang, Sien Hu, Su Chen Fang, Chi Shin Wu, Wei Ti Chen, Tony Szu Hsien Lee, Pau Chung Chen, Chiang Shan R. Li

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Substance misuse is associated with cognitive dysfunction. We used a stop signal task to examine deficits in cognitive control in individuals with opioid dependence (OD). We examined how response inhibition and post-error slowing are compromised and whether methadone maintenance treatment (MMT), abstinence duration, and psychiatric comorbidity are related to these measures in individuals with OD. Methods: Two-hundred-and-sixty-four men with OD who were incarcerated at a detention center and abstinent for up to 2 months (n = 108) or at a correctional facility and abstinent for approximately 6 months (n = 156), 65 OD men under MMT at a psychiatric clinic, and 64 age and education matched healthy control (HC) participants were assessed. We computed the stop signal reaction time (SSRT) to index the capacity of response inhibition and post-error slowing (PES) to represent errorrelated behavioral adjustment, as in our previous work. We examined group effects with analyses of variance and covariance analyses, followed by planned comparisons. Specifically, we compared OD and HC participants to examine the effects of opioid dependence and MMT and compared OD sub-groups to examine the effects of abstinence duration and psychiatric comorbidity. Results: The SSRT was significantly prolonged in OD but not MMT individuals, as compared to HC. The extent of post-error slowing diminished in OD and MMT, as compared to HC (trend; p = 0.061), and there was no difference between the OD and MMT groups. Individuals in longer abstinence were no less impaired in these measures. Furthermore, these results remained when psychiatric comorbidities including misuse of other substances were accounted for. Conclusions: Methadone treatment appears to be associated with relatively intact cognitive control in opioid dependent individuals. MMT may facilitate public health by augmenting cognitive control and thereby mitigating risky behaviors in heroin addicts.

Original languageEnglish
Article numbere94589
JournalPloS one
Volume9
Issue number4
DOIs
Publication statusPublished - 2014 Apr 11

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methadone
Methadone
narcotics
Opioid Analgesics
Psychiatry
Therapeutics
Comorbidity
Reaction Time
Analysis of Variance
Healthy Volunteers
correctional institutions
Social Adjustment
duration
group effect
Heroin
Public health
education
public health

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Liao, D. L., Huang, C. Y., Hu, S., Fang, S. C., Wu, C. S., Chen, W. T., ... Li, C. S. R. (2014). Cognitive control in opioid dependence and methadone maintenance treatment. PloS one, 9(4), [e94589]. https://doi.org/10.1371/journal.pone.0094589

Cognitive control in opioid dependence and methadone maintenance treatment. / Liao, Ding Lieh; Huang, Cheng Yi; Hu, Sien; Fang, Su Chen; Wu, Chi Shin; Chen, Wei Ti; Lee, Tony Szu Hsien; Chen, Pau Chung; Li, Chiang Shan R.

In: PloS one, Vol. 9, No. 4, e94589, 11.04.2014.

Research output: Contribution to journalArticle

Liao, DL, Huang, CY, Hu, S, Fang, SC, Wu, CS, Chen, WT, Lee, TSH, Chen, PC & Li, CSR 2014, 'Cognitive control in opioid dependence and methadone maintenance treatment', PloS one, vol. 9, no. 4, e94589. https://doi.org/10.1371/journal.pone.0094589
Liao DL, Huang CY, Hu S, Fang SC, Wu CS, Chen WT et al. Cognitive control in opioid dependence and methadone maintenance treatment. PloS one. 2014 Apr 11;9(4). e94589. https://doi.org/10.1371/journal.pone.0094589
Liao, Ding Lieh ; Huang, Cheng Yi ; Hu, Sien ; Fang, Su Chen ; Wu, Chi Shin ; Chen, Wei Ti ; Lee, Tony Szu Hsien ; Chen, Pau Chung ; Li, Chiang Shan R. / Cognitive control in opioid dependence and methadone maintenance treatment. In: PloS one. 2014 ; Vol. 9, No. 4.
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