Chiral separation of 3,4-methylenedioxymeth-amphetamine and related compounds in clandestine tablets and urine samples by capillary electrophoresis/fluorescence spectroscopy

Yu San Huang, Ju Tsung Liu, Li Chang Lin, Cheng-Huang Lin

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The R-(-)- and S-(+)-isomers of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA) were prepared, identified by gas chromatography/mass spectrometry (GC/MS) and then used as standards in a series of capillary electrophoresis (CE) experiments. Using these R-(-)- and S-(+)- isomers, the distribution of (RS)-MDA and (RS)-MDMA stereoisomers in clandestine tablets and suspect urine samples were identified. Several electrophoretic parameters, such as the concentration of β-cyclodextrin used in the electrophoretic separation and the amount of organic solvents required for the separation, were optimized.

Original languageEnglish
Pages (from-to)1097-1104
Number of pages8
JournalElectrophoresis
Volume24
Issue number6
DOIs
Publication statusPublished - 2003 Mar 1

Fingerprint

N-Methyl-3,4-methylenedioxyamphetamine
Capillary electrophoresis
Fluorescence Spectrometry
Fluorescence spectroscopy
Capillary Electrophoresis
Amphetamine
Isomers
Tablets
3,4-Methylenedioxyamphetamine
Urine
Stereoisomerism
Cyclodextrins
Metabolites
Gas chromatography
Gas Chromatography-Mass Spectrometry
Organic solvents
Mass spectrometry
Experiments

Keywords

  • Capillary electrophoresis
  • Chiral separation
  • Clandestine tablet
  • Designer drug
  • Gas chromatography-mass spectrometry
  • Urine

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

Cite this

Chiral separation of 3,4-methylenedioxymeth-amphetamine and related compounds in clandestine tablets and urine samples by capillary electrophoresis/fluorescence spectroscopy. / Huang, Yu San; Liu, Ju Tsung; Lin, Li Chang; Lin, Cheng-Huang.

In: Electrophoresis, Vol. 24, No. 6, 01.03.2003, p. 1097-1104.

Research output: Contribution to journalArticle

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