Abstract
A novel, organobase-catalyzed and highly chemoselective Michael-Michael-acetalization cascade is presented for the efficient synthesis of spiro-indandione skeletons. Following this very simple protocol, a broad range of products was obtained in good yields with excellent diastereocontrol. The role of steric factors in the acetalization step was evaluated.
| Original language | English |
|---|---|
| Pages (from-to) | 9182-9190 |
| Number of pages | 9 |
| Journal | Journal of Organic Chemistry |
| Volume | 82 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - 2017 Sep 1 |
ASJC Scopus subject areas
- Organic Chemistry
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Yang, S. M., Tsai, Y. L., Reddy, G. M., Möhlmann, L., & Lin, W. (2017). Chemo- and Diastereoselective Michael-Michael-Acetalization Cascade for the Synthesis of 1,3-Indandione-Fused Spiro[4.5]decan Scaffolds. Journal of Organic Chemistry, 82(17), 9182-9190. https://doi.org/10.1021/acs.joc.7b01415