Chemo- and Diastereoselective Michael-Michael-Acetalization Cascade for the Synthesis of 1,3-Indandione-Fused Spiro[4.5]decan Scaffolds

Shu Mei Yang, Yi Ling Tsai, Ganapuram Madhusudhan Reddy, Lennart Möhlmann, Wenwei Lin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A novel, organobase-catalyzed and highly chemoselective Michael-Michael-acetalization cascade is presented for the efficient synthesis of spiro-indandione skeletons. Following this very simple protocol, a broad range of products was obtained in good yields with excellent diastereocontrol. The role of steric factors in the acetalization step was evaluated.

Original languageEnglish
Pages (from-to)9182-9190
Number of pages9
JournalJournal of Organic Chemistry
Volume82
Issue number17
DOIs
Publication statusPublished - 2017 Sep 1

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ASJC Scopus subject areas

  • Organic Chemistry

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