ChemiRs

A web application for microRNAs and chemicals

Emily Chia Yu Su, Yu Sing Chen, Yun Cheng Tien, Jeff Liu, Bing Ching Ho, Sung Liang Yu, Sher Singh

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: MicroRNAs (miRNAs) are about 22 nucleotides, non-coding RNAs that affect various cellular functions, and play a regulatory role in different organisms including human. Until now, more than 2500 mature miRNAs in human have been discovered and registered, but still lack of information or algorithms to reveal the relations among miRNAs, environmental chemicals and human health. Chemicals in environment affect our health and daily life, and some of them can lead to diseases by inferring biological pathways. Results: We develop a creditable online web server, ChemiRs, for predicting interactions and relations among miRNAs, chemicals and pathways. The database not only compares gene lists affected by chemicals and miRNAs, but also incorporates curated pathways to identify possible interactions. Conclusions: Here, we manually retrieved associations of miRNAs and chemicals from biomedical literature. We developed an online system, ChemiRs, which contains miRNAs, diseases, Medical Subject Heading (MeSH) terms, chemicals, genes, pathways and PubMed IDs. We connected each miRNA to miRBase, and every current gene symbol to HUGO Gene Nomenclature Committee (HGNC) for genome annotation. Human pathway information is also provided from KEGG and REACTOME databases. Information about Gene Ontology (GO) is queried from GO Online SQL Environment (GOOSE). With a user-friendly interface, the web application is easy to use. Multiple query results can be easily integrated and exported as report documents in PDF format. Association analysis of miRNAs and chemicals can help us understand the pathogenesis of chemical components. ChemiRs is freely available for public use at http://omics.biol.ntnu.edu.tw/ChemiRs.

Original languageEnglish
Article number167
JournalBMC Bioinformatics
Volume17
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

MicroRNA
Web Application
MicroRNAs
Genes
Pathway
Gene
Gene Ontology
Ontology
Health
Medical Subject Headings
Databases
Online Systems
Online systems
Untranslated RNA
Terminology
Nucleotides
RNA
Web Server
User interfaces
Interaction

Keywords

  • Chemical
  • Disease
  • Gene ontology
  • Genomics
  • MicroRNA

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Applied Mathematics

Cite this

Su, E. C. Y., Chen, Y. S., Tien, Y. C., Liu, J., Ho, B. C., Yu, S. L., & Singh, S. (2016). ChemiRs: A web application for microRNAs and chemicals. BMC Bioinformatics, 17(1), [167]. https://doi.org/10.1186/s12859-016-1002-0

ChemiRs : A web application for microRNAs and chemicals. / Su, Emily Chia Yu; Chen, Yu Sing; Tien, Yun Cheng; Liu, Jeff; Ho, Bing Ching; Yu, Sung Liang; Singh, Sher.

In: BMC Bioinformatics, Vol. 17, No. 1, 167, 01.01.2016.

Research output: Contribution to journalArticle

Su, ECY, Chen, YS, Tien, YC, Liu, J, Ho, BC, Yu, SL & Singh, S 2016, 'ChemiRs: A web application for microRNAs and chemicals', BMC Bioinformatics, vol. 17, no. 1, 167. https://doi.org/10.1186/s12859-016-1002-0
Su ECY, Chen YS, Tien YC, Liu J, Ho BC, Yu SL et al. ChemiRs: A web application for microRNAs and chemicals. BMC Bioinformatics. 2016 Jan 1;17(1). 167. https://doi.org/10.1186/s12859-016-1002-0
Su, Emily Chia Yu ; Chen, Yu Sing ; Tien, Yun Cheng ; Liu, Jeff ; Ho, Bing Ching ; Yu, Sung Liang ; Singh, Sher. / ChemiRs : A web application for microRNAs and chemicals. In: BMC Bioinformatics. 2016 ; Vol. 17, No. 1.
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