Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase

Yuen Jen Wu; Chen Chieh Liao; Cheng Hung Jen; Yu Chiao Shih; Tun Cheng Chien

doi:10.1039/c001865a

Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase

Yuen Jen Wu, Chen Chieh Liao, Cheng Hung Jen, Yu Chiao Shih, Tun Cheng Chien^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The reactions of 6-cyano-1,3-dimethyluracil have been studied as chemical models to illustrate the mechanism for the transformation of 6-cyanouridine 5′-monophosphate (6-CN-UMP) to barbiturate ribonucleoside 5′-monophosphate (BMP) catalyzed by orotidine 5′-monophosphate decarboxylase (ODCase). The results suggest that the Asp residue in the ODCase active site plays the role of a general base in the transformation.

Original language	English
Pages (from-to)	4821-4823
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	26
DOIs	https://doi.org/10.1039/c001865a
Publication status	Published - 2010 Jul 14

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c001865a

Cite this

@article{8023279e8c4044909d7946ca49471cd6,

title = "Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase",

abstract = "The reactions of 6-cyano-1,3-dimethyluracil have been studied as chemical models to illustrate the mechanism for the transformation of 6-cyanouridine 5′-monophosphate (6-CN-UMP) to barbiturate ribonucleoside 5′-monophosphate (BMP) catalyzed by orotidine 5′-monophosphate decarboxylase (ODCase). The results suggest that the Asp residue in the ODCase active site plays the role of a general base in the transformation.",

author = "Wu, {Yuen Jen} and Liao, {Chen Chieh} and Jen, {Cheng Hung} and Shih, {Yu Chiao} and Chien, {Tun Cheng}",

year = "2010",

month = jul,

day = "14",

doi = "10.1039/c001865a",

language = "English",

volume = "46",

pages = "4821--4823",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "26",

}

TY - JOUR

T1 - Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase

AU - Wu, Yuen Jen

AU - Liao, Chen Chieh

AU - Jen, Cheng Hung

AU - Shih, Yu Chiao

AU - Chien, Tun Cheng

PY - 2010/7/14

Y1 - 2010/7/14

N2 - The reactions of 6-cyano-1,3-dimethyluracil have been studied as chemical models to illustrate the mechanism for the transformation of 6-cyanouridine 5′-monophosphate (6-CN-UMP) to barbiturate ribonucleoside 5′-monophosphate (BMP) catalyzed by orotidine 5′-monophosphate decarboxylase (ODCase). The results suggest that the Asp residue in the ODCase active site plays the role of a general base in the transformation.

AB - The reactions of 6-cyano-1,3-dimethyluracil have been studied as chemical models to illustrate the mechanism for the transformation of 6-cyanouridine 5′-monophosphate (6-CN-UMP) to barbiturate ribonucleoside 5′-monophosphate (BMP) catalyzed by orotidine 5′-monophosphate decarboxylase (ODCase). The results suggest that the Asp residue in the ODCase active site plays the role of a general base in the transformation.

UR - http://www.scopus.com/inward/record.url?scp=77953902515&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953902515&partnerID=8YFLogxK

U2 - 10.1039/c001865a

DO - 10.1039/c001865a

M3 - Article

C2 - 20498911

AN - SCOPUS:77953902515

SN - 1359-7345

VL - 46

SP - 4821

EP - 4823

JO - Chemical Communications

JF - Chemical Communications

IS - 26

ER -

Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this