Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase

Yuen Jen Wu, Chen Chieh Liao, Cheng Hung Jen, Yu Chiao Shih, Tun-Cheng Chien

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The reactions of 6-cyano-1,3-dimethyluracil have been studied as chemical models to illustrate the mechanism for the transformation of 6-cyanouridine 5′-monophosphate (6-CN-UMP) to barbiturate ribonucleoside 5′-monophosphate (BMP) catalyzed by orotidine 5′-monophosphate decarboxylase (ODCase). The results suggest that the Asp residue in the ODCase active site plays the role of a general base in the transformation.

Original languageEnglish
Pages (from-to)4821-4823
Number of pages3
JournalChemical Communications
Volume46
Issue number26
DOIs
Publication statusPublished - 2010 Jul 14

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ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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