Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase.

Tun Cheng Chien, Cheng Hung Jen, Yuen Jen Wu, Chen Chieh Liao

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1 Citation (Scopus)

Abstract

Orotidine 5'-monophosphate decarboxylase (ODCase) catalyzes an unprecedented transformation of 6- cyanouridine 5'-monophosphate (6-CN-UMP) into barbiturate nucleoside 5'-monophosphate (6-hydroxyuridine 5'-monophosphate, BMP). The reactions of 6- cyano-1,3-dimethyluracil toward various nucleophilic conditions have been studied as chemical models in order to understand the possible mechanism for the ODCase-catalyzed transformation of 6-CN-UMP.

Original languageEnglish
Pages (from-to)297-298
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number52
Publication statusPublished - 2008 Dec 1

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Chemical Models
Carboxy-Lyases
orotidylic acid
6-hydroxyuridine 5'-monophosphate
6-cyanouridine 5'-O-monophosphate
1,3-dimethyluracil

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "Orotidine 5'-monophosphate decarboxylase (ODCase) catalyzes an unprecedented transformation of 6- cyanouridine 5'-monophosphate (6-CN-UMP) into barbiturate nucleoside 5'-monophosphate (6-hydroxyuridine 5'-monophosphate, BMP). The reactions of 6- cyano-1,3-dimethyluracil toward various nucleophilic conditions have been studied as chemical models in order to understand the possible mechanism for the ODCase-catalyzed transformation of 6-CN-UMP.",
author = "Chien, {Tun Cheng} and Jen, {Cheng Hung} and Wu, {Yuen Jen} and Liao, {Chen Chieh}",
year = "2008",
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pages = "297--298",
journal = "Nucleic acids symposium series (2004)",
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AU - Chien, Tun Cheng

AU - Jen, Cheng Hung

AU - Wu, Yuen Jen

AU - Liao, Chen Chieh

PY - 2008/12/1

Y1 - 2008/12/1

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AB - Orotidine 5'-monophosphate decarboxylase (ODCase) catalyzes an unprecedented transformation of 6- cyanouridine 5'-monophosphate (6-CN-UMP) into barbiturate nucleoside 5'-monophosphate (6-hydroxyuridine 5'-monophosphate, BMP). The reactions of 6- cyano-1,3-dimethyluracil toward various nucleophilic conditions have been studied as chemical models in order to understand the possible mechanism for the ODCase-catalyzed transformation of 6-CN-UMP.

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