Chemical enhancer induced changes in the mechanisms of transdermal delivery of zinc oxide nanoparticles

Tsung Rong Kuo, Chung Long Wu, Chih Ting Hsu, Wen Lo, Shu Jen Chiang, Sung Jan Lin, Chen Yuan Dong, Chia Chun Chen

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

The overlapping wavelength of photoluminescence (PL) of zinc oxide nanoparticles (ZnO NPs) and autofluorescence (AF) from the stratum corneum (SC) has for a long time held back researchers from investigating the chemically enhanced penetration pathways of ZnO NPs into the SC lipids. However, the non-linear polarization effect of second harmonic generation (SHG) may be used for ZnO NPs to be distinguished from the AF of the SC. This study combined the SHG of ZnO NPs and the AF of the SC to image the transdermal delivery of ZnO NPs under the chemical enhancer conditions of oleic acid (OA), ethanol (EtOH) and oleic acid-ethanol (OA-EtOH). In addition to qualitative imaging, the microtransport properties of ZnO NPs were quantified to give the enhancements of the vehicle-to-skin partition coefficient (K), the SHG intensity gradient (G) and the effective diffusion path length (L). The results showed that OA, EtOH and OA-EtOH were all capable of enhancing the transdermal delivery of ZnO NPs by increasing the intercellular lipid fluidity or extracting lipids from the SC.

Original languageEnglish
Pages (from-to)3002-3008
Number of pages7
JournalBiomaterials
Volume30
Issue number16
DOIs
Publication statusPublished - 2009 Jun 1

Fingerprint

Zinc Oxide
Zinc oxide
Nanoparticles
Oleic acid
Oleic Acid
Cornea
Harmonic generation
Lipids
Ethanol
Fluidity
Skin
Photoluminescence
Research Personnel
Polarization
Imaging techniques
Wavelength

Keywords

  • Chemical enhancer
  • Second harmonic generation
  • Transdermal
  • Two-photon microscopy
  • ZnO nanoparticles

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Chemical enhancer induced changes in the mechanisms of transdermal delivery of zinc oxide nanoparticles. / Kuo, Tsung Rong; Wu, Chung Long; Hsu, Chih Ting; Lo, Wen; Chiang, Shu Jen; Lin, Sung Jan; Dong, Chen Yuan; Chen, Chia Chun.

In: Biomaterials, Vol. 30, No. 16, 01.06.2009, p. 3002-3008.

Research output: Contribution to journalArticle

Kuo, Tsung Rong ; Wu, Chung Long ; Hsu, Chih Ting ; Lo, Wen ; Chiang, Shu Jen ; Lin, Sung Jan ; Dong, Chen Yuan ; Chen, Chia Chun. / Chemical enhancer induced changes in the mechanisms of transdermal delivery of zinc oxide nanoparticles. In: Biomaterials. 2009 ; Vol. 30, No. 16. pp. 3002-3008.
@article{54db50c03bee425e8409ccb4530b2b08,
title = "Chemical enhancer induced changes in the mechanisms of transdermal delivery of zinc oxide nanoparticles",
abstract = "The overlapping wavelength of photoluminescence (PL) of zinc oxide nanoparticles (ZnO NPs) and autofluorescence (AF) from the stratum corneum (SC) has for a long time held back researchers from investigating the chemically enhanced penetration pathways of ZnO NPs into the SC lipids. However, the non-linear polarization effect of second harmonic generation (SHG) may be used for ZnO NPs to be distinguished from the AF of the SC. This study combined the SHG of ZnO NPs and the AF of the SC to image the transdermal delivery of ZnO NPs under the chemical enhancer conditions of oleic acid (OA), ethanol (EtOH) and oleic acid-ethanol (OA-EtOH). In addition to qualitative imaging, the microtransport properties of ZnO NPs were quantified to give the enhancements of the vehicle-to-skin partition coefficient (K), the SHG intensity gradient (G) and the effective diffusion path length (L). The results showed that OA, EtOH and OA-EtOH were all capable of enhancing the transdermal delivery of ZnO NPs by increasing the intercellular lipid fluidity or extracting lipids from the SC.",
keywords = "Chemical enhancer, Second harmonic generation, Transdermal, Two-photon microscopy, ZnO nanoparticles",
author = "Kuo, {Tsung Rong} and Wu, {Chung Long} and Hsu, {Chih Ting} and Wen Lo and Chiang, {Shu Jen} and Lin, {Sung Jan} and Dong, {Chen Yuan} and Chen, {Chia Chun}",
year = "2009",
month = "6",
day = "1",
doi = "10.1016/j.biomaterials.2009.02.003",
language = "English",
volume = "30",
pages = "3002--3008",
journal = "Biomaterials",
issn = "0142-9612",
publisher = "Elsevier BV",
number = "16",

}

TY - JOUR

T1 - Chemical enhancer induced changes in the mechanisms of transdermal delivery of zinc oxide nanoparticles

AU - Kuo, Tsung Rong

AU - Wu, Chung Long

AU - Hsu, Chih Ting

AU - Lo, Wen

AU - Chiang, Shu Jen

AU - Lin, Sung Jan

AU - Dong, Chen Yuan

AU - Chen, Chia Chun

PY - 2009/6/1

Y1 - 2009/6/1

N2 - The overlapping wavelength of photoluminescence (PL) of zinc oxide nanoparticles (ZnO NPs) and autofluorescence (AF) from the stratum corneum (SC) has for a long time held back researchers from investigating the chemically enhanced penetration pathways of ZnO NPs into the SC lipids. However, the non-linear polarization effect of second harmonic generation (SHG) may be used for ZnO NPs to be distinguished from the AF of the SC. This study combined the SHG of ZnO NPs and the AF of the SC to image the transdermal delivery of ZnO NPs under the chemical enhancer conditions of oleic acid (OA), ethanol (EtOH) and oleic acid-ethanol (OA-EtOH). In addition to qualitative imaging, the microtransport properties of ZnO NPs were quantified to give the enhancements of the vehicle-to-skin partition coefficient (K), the SHG intensity gradient (G) and the effective diffusion path length (L). The results showed that OA, EtOH and OA-EtOH were all capable of enhancing the transdermal delivery of ZnO NPs by increasing the intercellular lipid fluidity or extracting lipids from the SC.

AB - The overlapping wavelength of photoluminescence (PL) of zinc oxide nanoparticles (ZnO NPs) and autofluorescence (AF) from the stratum corneum (SC) has for a long time held back researchers from investigating the chemically enhanced penetration pathways of ZnO NPs into the SC lipids. However, the non-linear polarization effect of second harmonic generation (SHG) may be used for ZnO NPs to be distinguished from the AF of the SC. This study combined the SHG of ZnO NPs and the AF of the SC to image the transdermal delivery of ZnO NPs under the chemical enhancer conditions of oleic acid (OA), ethanol (EtOH) and oleic acid-ethanol (OA-EtOH). In addition to qualitative imaging, the microtransport properties of ZnO NPs were quantified to give the enhancements of the vehicle-to-skin partition coefficient (K), the SHG intensity gradient (G) and the effective diffusion path length (L). The results showed that OA, EtOH and OA-EtOH were all capable of enhancing the transdermal delivery of ZnO NPs by increasing the intercellular lipid fluidity or extracting lipids from the SC.

KW - Chemical enhancer

KW - Second harmonic generation

KW - Transdermal

KW - Two-photon microscopy

KW - ZnO nanoparticles

UR - http://www.scopus.com/inward/record.url?scp=63649142562&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=63649142562&partnerID=8YFLogxK

U2 - 10.1016/j.biomaterials.2009.02.003

DO - 10.1016/j.biomaterials.2009.02.003

M3 - Article

VL - 30

SP - 3002

EP - 3008

JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

IS - 16

ER -