Chemical enhancer induced changes in the mechanisms of transdermal delivery of zinc oxide nanoparticles

Tsung Rong Kuo, Chung Long Wu, Chih Ting Hsu, Wen Lo, Shu Jen Chiang, Sung Jan Lin, Chen Yuan Dong, Chia Chun Chen

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81 Citations (Scopus)

Abstract

The overlapping wavelength of photoluminescence (PL) of zinc oxide nanoparticles (ZnO NPs) and autofluorescence (AF) from the stratum corneum (SC) has for a long time held back researchers from investigating the chemically enhanced penetration pathways of ZnO NPs into the SC lipids. However, the non-linear polarization effect of second harmonic generation (SHG) may be used for ZnO NPs to be distinguished from the AF of the SC. This study combined the SHG of ZnO NPs and the AF of the SC to image the transdermal delivery of ZnO NPs under the chemical enhancer conditions of oleic acid (OA), ethanol (EtOH) and oleic acid-ethanol (OA-EtOH). In addition to qualitative imaging, the microtransport properties of ZnO NPs were quantified to give the enhancements of the vehicle-to-skin partition coefficient (K), the SHG intensity gradient (G) and the effective diffusion path length (L). The results showed that OA, EtOH and OA-EtOH were all capable of enhancing the transdermal delivery of ZnO NPs by increasing the intercellular lipid fluidity or extracting lipids from the SC.

Original languageEnglish
Pages (from-to)3002-3008
Number of pages7
JournalBiomaterials
Volume30
Issue number16
DOIs
Publication statusPublished - 2009 Jun 1

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Keywords

  • Chemical enhancer
  • Second harmonic generation
  • Transdermal
  • Two-photon microscopy
  • ZnO nanoparticles

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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