Characterizing longitudinal and transverse relaxation rates of ferrofluids in microtesla magnetic fields

Ming Jye Chen, Shu-Hsien Liao, Hong-Chang Yang, Hsin Yi Lee, Yi Jia Liu, Hsin Hsien Chen, Herng-Er Horng, Shieh-Yueh Yang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Shortening spin-lattice relaxation rates (1/T 1) or spin-spin relaxation rates (1/T 2) is the purpose of magnetic resonance imaging contrast agents. In this work, an ultralow field nuclear magnetic resonance spectrometer and imager are set up to characterize the spin relaxation rates of Fe 3O 4 superparamagnetic iron oxide (SPIO) for image contrast. It was found that both 1/T 1 and 1/T 2 increase linearly when the magnetic susceptibility of SPIO increases by increasing the concentration of SPIO dispersed in water. In an applied field, magnetic moments of SPIO generate microscopic field gradients that weaken the field homogeneity, in turn de-phasing the proton's nuclear spin and enhancing the relaxation rates. A T 1-contrast image is demonstrated, using SPIO as the contrast agent and high-T c superconducting quantum interference devices as the detector. T 1-contrast imaging in microtesla fields might provide a potential modality for discriminating cancer.

Original languageEnglish
Article number123911
JournalJournal of Applied Physics
Volume110
Issue number12
DOIs
Publication statusPublished - 2011 Dec 15

Fingerprint

ferrofluids
iron oxides
magnetic fields
image contrast
spin-lattice relaxation
nuclear spin
homogeneity
magnetic resonance
magnetic moments
cancer
spectrometers
magnetic permeability
interference
gradients
nuclear magnetic resonance
protons
detectors
water

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Characterizing longitudinal and transverse relaxation rates of ferrofluids in microtesla magnetic fields. / Chen, Ming Jye; Liao, Shu-Hsien; Yang, Hong-Chang; Lee, Hsin Yi; Liu, Yi Jia; Chen, Hsin Hsien; Horng, Herng-Er; Yang, Shieh-Yueh.

In: Journal of Applied Physics, Vol. 110, No. 12, 123911, 15.12.2011.

Research output: Contribution to journalArticle

Chen, Ming Jye ; Liao, Shu-Hsien ; Yang, Hong-Chang ; Lee, Hsin Yi ; Liu, Yi Jia ; Chen, Hsin Hsien ; Horng, Herng-Er ; Yang, Shieh-Yueh. / Characterizing longitudinal and transverse relaxation rates of ferrofluids in microtesla magnetic fields. In: Journal of Applied Physics. 2011 ; Vol. 110, No. 12.
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