Characterizing longitudinal and transverse relaxation rates of ferrofluids in microtesla magnetic fields

Ming Jye Chen, Shu-Hsien Liao, Hong-Chang Yang, Hsin Yi Lee, Yi Jia Liu, Hsin Hsien Chen, Herng-Er Horng, Shieh-Yueh Yang

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Shortening spin-lattice relaxation rates (1/T 1) or spin-spin relaxation rates (1/T 2) is the purpose of magnetic resonance imaging contrast agents. In this work, an ultralow field nuclear magnetic resonance spectrometer and imager are set up to characterize the spin relaxation rates of Fe 3O 4 superparamagnetic iron oxide (SPIO) for image contrast. It was found that both 1/T 1 and 1/T 2 increase linearly when the magnetic susceptibility of SPIO increases by increasing the concentration of SPIO dispersed in water. In an applied field, magnetic moments of SPIO generate microscopic field gradients that weaken the field homogeneity, in turn de-phasing the proton's nuclear spin and enhancing the relaxation rates. A T 1-contrast image is demonstrated, using SPIO as the contrast agent and high-T c superconducting quantum interference devices as the detector. T 1-contrast imaging in microtesla fields might provide a potential modality for discriminating cancer.

    Original languageEnglish
    Article number123911
    JournalJournal of Applied Physics
    Volume110
    Issue number12
    DOIs
    Publication statusPublished - 2011 Dec 15

    Fingerprint

    ferrofluids
    iron oxides
    magnetic fields
    image contrast
    spin-lattice relaxation
    nuclear spin
    homogeneity
    magnetic resonance
    magnetic moments
    cancer
    spectrometers
    magnetic permeability
    interference
    gradients
    nuclear magnetic resonance
    protons
    detectors
    water

    ASJC Scopus subject areas

    • Physics and Astronomy(all)

    Cite this

    Characterizing longitudinal and transverse relaxation rates of ferrofluids in microtesla magnetic fields. / Chen, Ming Jye; Liao, Shu-Hsien; Yang, Hong-Chang; Lee, Hsin Yi; Liu, Yi Jia; Chen, Hsin Hsien; Horng, Herng-Er; Yang, Shieh-Yueh.

    In: Journal of Applied Physics, Vol. 110, No. 12, 123911, 15.12.2011.

    Research output: Contribution to journalArticle

    Chen, Ming Jye ; Liao, Shu-Hsien ; Yang, Hong-Chang ; Lee, Hsin Yi ; Liu, Yi Jia ; Chen, Hsin Hsien ; Horng, Herng-Er ; Yang, Shieh-Yueh. / Characterizing longitudinal and transverse relaxation rates of ferrofluids in microtesla magnetic fields. In: Journal of Applied Physics. 2011 ; Vol. 110, No. 12.
    @article{681ea147c56d4d15913e0f759c71b262,
    title = "Characterizing longitudinal and transverse relaxation rates of ferrofluids in microtesla magnetic fields",
    abstract = "Shortening spin-lattice relaxation rates (1/T 1) or spin-spin relaxation rates (1/T 2) is the purpose of magnetic resonance imaging contrast agents. In this work, an ultralow field nuclear magnetic resonance spectrometer and imager are set up to characterize the spin relaxation rates of Fe 3O 4 superparamagnetic iron oxide (SPIO) for image contrast. It was found that both 1/T 1 and 1/T 2 increase linearly when the magnetic susceptibility of SPIO increases by increasing the concentration of SPIO dispersed in water. In an applied field, magnetic moments of SPIO generate microscopic field gradients that weaken the field homogeneity, in turn de-phasing the proton's nuclear spin and enhancing the relaxation rates. A T 1-contrast image is demonstrated, using SPIO as the contrast agent and high-T c superconducting quantum interference devices as the detector. T 1-contrast imaging in microtesla fields might provide a potential modality for discriminating cancer.",
    author = "Chen, {Ming Jye} and Shu-Hsien Liao and Hong-Chang Yang and Lee, {Hsin Yi} and Liu, {Yi Jia} and Chen, {Hsin Hsien} and Herng-Er Horng and Shieh-Yueh Yang",
    year = "2011",
    month = "12",
    day = "15",
    doi = "10.1063/1.3671420",
    language = "English",
    volume = "110",
    journal = "Journal of Applied Physics",
    issn = "0021-8979",
    publisher = "American Institute of Physics Publising LLC",
    number = "12",

    }

    TY - JOUR

    T1 - Characterizing longitudinal and transverse relaxation rates of ferrofluids in microtesla magnetic fields

    AU - Chen, Ming Jye

    AU - Liao, Shu-Hsien

    AU - Yang, Hong-Chang

    AU - Lee, Hsin Yi

    AU - Liu, Yi Jia

    AU - Chen, Hsin Hsien

    AU - Horng, Herng-Er

    AU - Yang, Shieh-Yueh

    PY - 2011/12/15

    Y1 - 2011/12/15

    N2 - Shortening spin-lattice relaxation rates (1/T 1) or spin-spin relaxation rates (1/T 2) is the purpose of magnetic resonance imaging contrast agents. In this work, an ultralow field nuclear magnetic resonance spectrometer and imager are set up to characterize the spin relaxation rates of Fe 3O 4 superparamagnetic iron oxide (SPIO) for image contrast. It was found that both 1/T 1 and 1/T 2 increase linearly when the magnetic susceptibility of SPIO increases by increasing the concentration of SPIO dispersed in water. In an applied field, magnetic moments of SPIO generate microscopic field gradients that weaken the field homogeneity, in turn de-phasing the proton's nuclear spin and enhancing the relaxation rates. A T 1-contrast image is demonstrated, using SPIO as the contrast agent and high-T c superconducting quantum interference devices as the detector. T 1-contrast imaging in microtesla fields might provide a potential modality for discriminating cancer.

    AB - Shortening spin-lattice relaxation rates (1/T 1) or spin-spin relaxation rates (1/T 2) is the purpose of magnetic resonance imaging contrast agents. In this work, an ultralow field nuclear magnetic resonance spectrometer and imager are set up to characterize the spin relaxation rates of Fe 3O 4 superparamagnetic iron oxide (SPIO) for image contrast. It was found that both 1/T 1 and 1/T 2 increase linearly when the magnetic susceptibility of SPIO increases by increasing the concentration of SPIO dispersed in water. In an applied field, magnetic moments of SPIO generate microscopic field gradients that weaken the field homogeneity, in turn de-phasing the proton's nuclear spin and enhancing the relaxation rates. A T 1-contrast image is demonstrated, using SPIO as the contrast agent and high-T c superconducting quantum interference devices as the detector. T 1-contrast imaging in microtesla fields might provide a potential modality for discriminating cancer.

    UR - http://www.scopus.com/inward/record.url?scp=84855309957&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84855309957&partnerID=8YFLogxK

    U2 - 10.1063/1.3671420

    DO - 10.1063/1.3671420

    M3 - Article

    VL - 110

    JO - Journal of Applied Physics

    JF - Journal of Applied Physics

    SN - 0021-8979

    IS - 12

    M1 - 123911

    ER -