Changes in blood bone markers after the first and second bouts of whole-body eccentric exercises

Tsang Hai Huang, Kazunori Nosaka, Trevor C. Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The present study compared the first (EC1) and second (EC2) bouts of whole-body eccentric exercises to examine the effects of the magnitude of muscle damage on changes in blood bone markers. Fifteen sedentary young men performed nine eccentric exercises of arm, leg, and trunk muscles, and repeated them 2 weeks later. Blood samples were taken before and 2 h and 1–5 days following each bout to analyze plasma creatine kinase (CK) activity and myoglobin concentration, serum tartrate-resistant acid phosphatase (TRAP), type 1 C-terminal telopeptide (CTX-1), procollagen type I N-terminal propeptide (P1NP), bone-specific alkaline phosphatase (BAP), undercarboxylated-osteocalcin (ucOCN), carboxylated-osteocalcin (cOCN), and leptin concentrations. All except ucOCN changed significantly (p < 0.05) after both bouts. When comparing bouts for peak changes, P1NP (bone formation marker) and CTX-1 (bone resorption marker) increased less after EC2 (peak: 137±96% and 7±6%, respectively) than after EC1 (146 ± 80% and 30 ± 21%, respectively), whereas BAP (bone formation marker) increased more after EC2 (18 ± 16%) than after EC1 (4 ± 15%) (p < 0.05). Leptin (49 ± 58%) and cOCN (14 ± 10%) increased more (p < 0.05) after EC2 than after EC1 (−30 ± 15%, 9 ± 26%). Significant (p < 0.05) correlations were evident between peak CK activity and peak CTX-1 (r = 0.847), P1NP (r = 0.815), BAP (r = −0.707), ucOCN (r = 0.627), cCON (r = −0.759), and leptin (r = −0.740) changes after EC1, but many of these correlations disappeared after EC2. This was also found for the relationships between other muscle damage markers (myoglobin, muscle soreness, and muscle strength) and the bone markers. It was concluded that bone turnover was affected by eccentric exercise, but muscle damage was unfavorable for bone formation.

Original languageEnglish
Pages (from-to)521-532
Number of pages12
JournalScandinavian Journal of Medicine and Science in Sports
Volume32
Issue number3
DOIs
Publication statusPublished - 2022 Mar

Keywords

  • C-terminal telopeptide of type I collagen
  • bone-specific alkaline phosphatase
  • creatine kinase activity
  • lengthening muscle action
  • muscle damage
  • procollagen type I c-terminal peptide
  • repeated bout effect
  • tartrate-resistant acid phosphatase

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Fingerprint

Dive into the research topics of 'Changes in blood bone markers after the first and second bouts of whole-body eccentric exercises'. Together they form a unique fingerprint.

Cite this