Cell proliferation inhibitory and apoptosis-inducing properties of anacardic acid and lunasin in human breast cancer MDA-MB-231 cells

Chia Chien Hsieh; Blanca Hernández-Ledesma; Ben O. de Lumen

doi:10.1016/j.foodchem.2010.09.051

Cell proliferation inhibitory and apoptosis-inducing properties of anacardic acid and lunasin in human breast cancer MDA-MB-231 cells

Chia Chien Hsieh, Blanca Hernández-Ledesma, Ben O. de Lumen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

The combination of two or more chemopreventive agents is currently being used to achieve greater inhibitory effects on breast cancer cells. Anacardic acid and lunasin are two plant-derived compounds that have been associated with anti-carcinogenic properties. These compounds show inhibitory effects on cell proliferation and inducing properties of apoptosis in human breast cancer MDA-MB-231 cell line. Both lunasin and anacardic acid exert their effects through the modulation of expression of several genes involved in cell cycle, apoptosis and signal transduction. Their combination arrests the cell cycle in S-phase and induces apoptosis at higher levels than that observed when each compound is used individually. This combination also promotes the inhibition of ERBB2, AKT1, JUN and RAF1 signalling gene expression, whose up-regulation has been reported as responsible for breast cancer cells growth and resistance to apoptosis. Our results introduce these two compounds as a promising strategy to prevent/treat breast cancer.

Original language	English
Pages (from-to)	630-636
Number of pages	7
Journal	Food Chemistry
Volume	125
Issue number	2
DOIs	https://doi.org/10.1016/j.foodchem.2010.09.051
Publication status	Published - 2011 Mar 15
Externally published	Yes

Keywords

Anacardic acid
Apoptosis
Breast cancer cells
Cell proliferation
Lunasin
Signal transduction genes

ASJC Scopus subject areas

Analytical Chemistry
Food Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.foodchem.2010.09.051

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@article{e2aed4dd5f7c4aafa9529b3e72d97b8b,

title = "Cell proliferation inhibitory and apoptosis-inducing properties of anacardic acid and lunasin in human breast cancer MDA-MB-231 cells",

abstract = "The combination of two or more chemopreventive agents is currently being used to achieve greater inhibitory effects on breast cancer cells. Anacardic acid and lunasin are two plant-derived compounds that have been associated with anti-carcinogenic properties. These compounds show inhibitory effects on cell proliferation and inducing properties of apoptosis in human breast cancer MDA-MB-231 cell line. Both lunasin and anacardic acid exert their effects through the modulation of expression of several genes involved in cell cycle, apoptosis and signal transduction. Their combination arrests the cell cycle in S-phase and induces apoptosis at higher levels than that observed when each compound is used individually. This combination also promotes the inhibition of ERBB2, AKT1, JUN and RAF1 signalling gene expression, whose up-regulation has been reported as responsible for breast cancer cells growth and resistance to apoptosis. Our results introduce these two compounds as a promising strategy to prevent/treat breast cancer.",

keywords = "Anacardic acid, Apoptosis, Breast cancer cells, Cell proliferation, Lunasin, Signal transduction genes",

author = "Hsieh, {Chia Chien} and Blanca Hern{\'a}ndez-Ledesma and {de Lumen}, {Ben O.}",

note = "Funding Information: The authors wish to thank the American Institute for Cancer Research (AICR) for partial research funding, and the European Commission and the Spanish National Research Council for the Marie-Curie post-doctoral fellowship awarded to Blanca Hern{\'a}ndez-Ledesma.",

year = "2011",

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day = "15",

doi = "10.1016/j.foodchem.2010.09.051",

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AU - Hsieh, Chia Chien

AU - Hernández-Ledesma, Blanca

AU - de Lumen, Ben O.

N1 - Funding Information: The authors wish to thank the American Institute for Cancer Research (AICR) for partial research funding, and the European Commission and the Spanish National Research Council for the Marie-Curie post-doctoral fellowship awarded to Blanca Hernández-Ledesma.

PY - 2011/3/15

Y1 - 2011/3/15

N2 - The combination of two or more chemopreventive agents is currently being used to achieve greater inhibitory effects on breast cancer cells. Anacardic acid and lunasin are two plant-derived compounds that have been associated with anti-carcinogenic properties. These compounds show inhibitory effects on cell proliferation and inducing properties of apoptosis in human breast cancer MDA-MB-231 cell line. Both lunasin and anacardic acid exert their effects through the modulation of expression of several genes involved in cell cycle, apoptosis and signal transduction. Their combination arrests the cell cycle in S-phase and induces apoptosis at higher levels than that observed when each compound is used individually. This combination also promotes the inhibition of ERBB2, AKT1, JUN and RAF1 signalling gene expression, whose up-regulation has been reported as responsible for breast cancer cells growth and resistance to apoptosis. Our results introduce these two compounds as a promising strategy to prevent/treat breast cancer.

AB - The combination of two or more chemopreventive agents is currently being used to achieve greater inhibitory effects on breast cancer cells. Anacardic acid and lunasin are two plant-derived compounds that have been associated with anti-carcinogenic properties. These compounds show inhibitory effects on cell proliferation and inducing properties of apoptosis in human breast cancer MDA-MB-231 cell line. Both lunasin and anacardic acid exert their effects through the modulation of expression of several genes involved in cell cycle, apoptosis and signal transduction. Their combination arrests the cell cycle in S-phase and induces apoptosis at higher levels than that observed when each compound is used individually. This combination also promotes the inhibition of ERBB2, AKT1, JUN and RAF1 signalling gene expression, whose up-regulation has been reported as responsible for breast cancer cells growth and resistance to apoptosis. Our results introduce these two compounds as a promising strategy to prevent/treat breast cancer.

KW - Anacardic acid

KW - Apoptosis

KW - Breast cancer cells

KW - Cell proliferation

KW - Lunasin

KW - Signal transduction genes

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SN - 0308-8146

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JO - Food Chemistry

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Cell proliferation inhibitory and apoptosis-inducing properties of anacardic acid and lunasin in human breast cancer MDA-MB-231 cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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