Cell proliferation inhibitory and apoptosis-inducing properties of anacardic acid and lunasin in human breast cancer MDA-MB-231 cells

Chia Chien Hsieh, Blanca Hernández-Ledesma, Ben O. de Lumen

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The combination of two or more chemopreventive agents is currently being used to achieve greater inhibitory effects on breast cancer cells. Anacardic acid and lunasin are two plant-derived compounds that have been associated with anti-carcinogenic properties. These compounds show inhibitory effects on cell proliferation and inducing properties of apoptosis in human breast cancer MDA-MB-231 cell line. Both lunasin and anacardic acid exert their effects through the modulation of expression of several genes involved in cell cycle, apoptosis and signal transduction. Their combination arrests the cell cycle in S-phase and induces apoptosis at higher levels than that observed when each compound is used individually. This combination also promotes the inhibition of ERBB2, AKT1, JUN and RAF1 signalling gene expression, whose up-regulation has been reported as responsible for breast cancer cells growth and resistance to apoptosis. Our results introduce these two compounds as a promising strategy to prevent/treat breast cancer.

Original languageEnglish
Pages (from-to)630-636
Number of pages7
JournalFood Chemistry
Volume125
Issue number2
DOIs
Publication statusPublished - 2011 Mar 15
Externally publishedYes

Keywords

  • Anacardic acid
  • Apoptosis
  • Breast cancer cells
  • Cell proliferation
  • Lunasin
  • Signal transduction genes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Food Science

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