Catalyst free conjugate addition of indoles and pyrroles to nitro alkenes under solvent free condition (SFC): An effective greener route to access 3-(2-nitro-1-phenylethyl)-1H-indole and 2-(2-nitro-1-phenylethyl)-1H-pyrrole derivatives

Pateliya Mujjamil Habib, Veerababurao Kavala, Chun Wei Kuo, Mustafa J. Raihan, Ching-Fa Yao

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Catalyst free conjugate addition of reactive hetero aromatics (pyrrole and indoles) to nitro alkenes under solvent free condition is described. This method provides several advantages, such as operational simplicity, solvent-free conditions and good yields of products. Also it is environmentally friendly and more cost effective alternative to existing protocols. Catalyst free conjugate addition of reactive hetero aromatics (pyrrole and indoles) to nitro alkenes under solvent free condition is described. This method provides several advantages, such as operational simplicity, solvent-free conditions and good yields of products. Also it is environmentally friendly and more cost effective alternative to existing protocols.

Original languageEnglish
Pages (from-to)7050-7056
Number of pages7
JournalTetrahedron
Volume66
Issue number34
DOIs
Publication statusPublished - 2010 Aug 21

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Indoles
Pyrroles
Alkenes
Derivatives
Catalysts
Costs and Cost Analysis
Costs
indole

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Catalyst free conjugate addition of indoles and pyrroles to nitro alkenes under solvent free condition (SFC) : An effective greener route to access 3-(2-nitro-1-phenylethyl)-1H-indole and 2-(2-nitro-1-phenylethyl)-1H-pyrrole derivatives. / Habib, Pateliya Mujjamil; Kavala, Veerababurao; Kuo, Chun Wei; Raihan, Mustafa J.; Yao, Ching-Fa.

In: Tetrahedron, Vol. 66, No. 34, 21.08.2010, p. 7050-7056.

Research output: Contribution to journalArticle

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