Catalyst-free aqueous-mediated conjugative addition of indoles to β-nitrostyrenes

Pateliya Mujjamil Habib; Veerababurao Kavala; Chun Wei Kuo; Ching Fa Yao

doi:10.1016/j.tetlet.2008.09.109

Catalyst-free aqueous-mediated conjugative addition of indoles to β-nitrostyrenes

Pateliya Mujjamil Habib, Veerababurao Kavala, Chun Wei Kuo, Ching Fa Yao

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

A catalyst free aqueous-mediated alkylation of indoles with various β-nitrostyrenes was performed at elevated temperature. No catalyst, clean reaction conditions, simple workup procedure, easy isolation, viability for large scale preparation, and environmentally acceptable medium are the best features in this process.

Original language	English
Pages (from-to)	7005-7007
Number of pages	3
Journal	Tetrahedron Letters
Volume	49
Issue number	49
DOIs	https://doi.org/10.1016/j.tetlet.2008.09.109
Publication status	Published - 2008 Dec 1

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Catalyst-free aqueous-mediated conjugative addition of indoles to β-nitrostyrenes",

abstract = "A catalyst free aqueous-mediated alkylation of indoles with various β-nitrostyrenes was performed at elevated temperature. No catalyst, clean reaction conditions, simple workup procedure, easy isolation, viability for large scale preparation, and environmentally acceptable medium are the best features in this process.",

author = "Habib, {Pateliya Mujjamil} and Veerababurao Kavala and Kuo, {Chun Wei} and Yao, {Ching Fa}",

note = "Funding Information: Financial support of this work by the National Science Council of the Republic of China and National Taiwan Normal University (TOP001) is gratefully acknowledged. ",

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AU - Habib, Pateliya Mujjamil

AU - Kavala, Veerababurao

AU - Kuo, Chun Wei

AU - Yao, Ching Fa

N1 - Funding Information: Financial support of this work by the National Science Council of the Republic of China and National Taiwan Normal University (TOP001) is gratefully acknowledged.

PY - 2008/12/1

Y1 - 2008/12/1

N2 - A catalyst free aqueous-mediated alkylation of indoles with various β-nitrostyrenes was performed at elevated temperature. No catalyst, clean reaction conditions, simple workup procedure, easy isolation, viability for large scale preparation, and environmentally acceptable medium are the best features in this process.

AB - A catalyst free aqueous-mediated alkylation of indoles with various β-nitrostyrenes was performed at elevated temperature. No catalyst, clean reaction conditions, simple workup procedure, easy isolation, viability for large scale preparation, and environmentally acceptable medium are the best features in this process.

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