Catalyst-free 1,3-dipolar cycloaddition of 3-nitrochromen with sodium azide: a facile method for the synthesis of 4-aryl-1,4-dihydrochromeno[4,3-d][1,2,3]triazole derivatives

Pateliya Mujjamil Habib, B. Rama Raju, Veerababurao Kavala, Chun Wei Kuo, Ching Fa Yao

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1,3-Dipolar cycloaddition of 3-nitrochromen with sodium azide under catalyst-free conditions afforded 4-aryl-1,4-dihydrochromeno[4,3-d][1,2,3]triazole derivatives at 80 °C in DMSO is described. The generality of this reaction was demonstrated by synthesizing an array of 4-aryl-1,4-dihydrochromeno[4,3-d][1,2,3]triazole derivatives. Clean reaction conditions, easy isolation, and good yields of the triazoles are the salient features of the methodology.

Original languageEnglish
Pages (from-to)5799-5804
Number of pages6
Issue number29-30
Publication statusPublished - 2009 Jul 18


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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