TY - JOUR
T1 - Cancer risk among gingivitis and periodontitis patients
T2 - A nationwide cohort study
AU - Wen, B. W.
AU - Tsai, C. S.
AU - Lin, C. L.
AU - Chang, Y. J.
AU - Lee, C. F.
AU - Hsu, C. H.
AU - Kao, C. H.
N1 - Funding Information:
The study was supported in part by grants from China Medical University Hospital (DMR-103-020), Tung’s Taichung MetroHarbor Hospital (TTM-TMU-96-06), the Taiwan Department of Health Clinical Trial and Research Center and for Excellence (DOH102-TD-B-111-004), Taiwan Department of Health Cancer Research Center of Excellence (DOH102-TD-C-111-005) and International Research-Intensive Centers of Excellence in Taiwan (NSC101-2911-I-002-303). B.-W.W. and C.-H.K: concept and design; C.-S.T., C.-F.L. and C.-H.H: provision of study materials or patient recruitment; C.-L.L. and Y.-J.C.: data collection and/or assembly; all authors: data analysis and interpretation, manuscript composition and final approval of the manuscript.
PY - 2014/4
Y1 - 2014/4
N2 - Aim: Periodontal disease encompasses gingivitis and periodontitis, which exerts systemic effects. We conducted a population-based study to evaluate the association between periodontal disease and the risk of cancer. Methods: We used insurance claims data from 1997 to 2010, accessing a database of 1 million randomly selected insurants in Taiwan. All patients were older than 20 and newly diagnosed with periodontitis between 1 January 1997 and 31 December 2010. The comparison cohort comprised patients older than 20, who were newly diagnosed with gingivitis in the same period. Both cohorts were followed until a cancer diagnosis, lost to follow-up, death, termination of insurance, or the end of 2010. Results: The incidence rate of cancer was 1.14 times higher in the study cohort than in the comparison cohort [confidence interval (CI) = 1.11-1.17]. The adjusted hazard ratio (HR) was 1.05 (95% CI = 1.00-1.11). A multivariable analysis showed that the periodontitis patients exhibited an elevated risk of developing oral cancer (adjusted HR = 1.79, 95% CI = 1.42-2.25). Conclusion: The findings indicated that patients in the periodontitis cohort exhibited a higher risk of developing oral cancer than those in the gingivitis cohort.
AB - Aim: Periodontal disease encompasses gingivitis and periodontitis, which exerts systemic effects. We conducted a population-based study to evaluate the association between periodontal disease and the risk of cancer. Methods: We used insurance claims data from 1997 to 2010, accessing a database of 1 million randomly selected insurants in Taiwan. All patients were older than 20 and newly diagnosed with periodontitis between 1 January 1997 and 31 December 2010. The comparison cohort comprised patients older than 20, who were newly diagnosed with gingivitis in the same period. Both cohorts were followed until a cancer diagnosis, lost to follow-up, death, termination of insurance, or the end of 2010. Results: The incidence rate of cancer was 1.14 times higher in the study cohort than in the comparison cohort [confidence interval (CI) = 1.11-1.17]. The adjusted hazard ratio (HR) was 1.05 (95% CI = 1.00-1.11). A multivariable analysis showed that the periodontitis patients exhibited an elevated risk of developing oral cancer (adjusted HR = 1.79, 95% CI = 1.42-2.25). Conclusion: The findings indicated that patients in the periodontitis cohort exhibited a higher risk of developing oral cancer than those in the gingivitis cohort.
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U2 - 10.1093/qjmed/hct248
DO - 10.1093/qjmed/hct248
M3 - Article
C2 - 24336850
AN - SCOPUS:84897100262
SN - 1460-2725
VL - 107
SP - 283
EP - 290
JO - QJM: An International Journal of Medicine
JF - QJM: An International Journal of Medicine
IS - 4
ER -
