TY - JOUR
T1 - Bisphenol A and phthalates exhibit similar toxicogenomics and health effects
AU - Singh, Sher
AU - Li, Steven Shoei Lung
N1 - Funding Information:
We thank Miss Zong-Yun Tsai for technical assistance and the microarray core facility of NTUCGM for IPA analysis. This investigation was supported in part by the National Science Council of Taiwan to S.S.-L. Li.
PY - 2012/2/15
Y1 - 2012/2/15
N2 - Plastics are widely used in modern life, and their unbound chemicals bisphenol A and phthalates can leach out into the surrounding environment. BPA and PAEs have recently attracted the special attention of the scientific community, regulatory agencies and the general public because of their high production volume, widespread use of plastics, and endocrine-disrupting effects. In The Comparative Toxicogenomics Database, BPA and five most frequently curated PAEs (DEHP/MEHP and DBP/BBP/MBP) were found to have 1932 and 484 interactions with genes/proteins, respectively. Five of their top ten toxicity networks were found to be involved in inflammation, and their top ten diseases included genital, prostatic, endomentrial, ovarian and breast diseases. BPA and PAEs were found to exhibit similar toxicogenomics and adverse effects on human health owning to their 89 common interacting genes/proteins. These 89 genes/proteins may serve as biomarkers to assay the toxicities of different chemicals leached out from the widely used plastics.
AB - Plastics are widely used in modern life, and their unbound chemicals bisphenol A and phthalates can leach out into the surrounding environment. BPA and PAEs have recently attracted the special attention of the scientific community, regulatory agencies and the general public because of their high production volume, widespread use of plastics, and endocrine-disrupting effects. In The Comparative Toxicogenomics Database, BPA and five most frequently curated PAEs (DEHP/MEHP and DBP/BBP/MBP) were found to have 1932 and 484 interactions with genes/proteins, respectively. Five of their top ten toxicity networks were found to be involved in inflammation, and their top ten diseases included genital, prostatic, endomentrial, ovarian and breast diseases. BPA and PAEs were found to exhibit similar toxicogenomics and adverse effects on human health owning to their 89 common interacting genes/proteins. These 89 genes/proteins may serve as biomarkers to assay the toxicities of different chemicals leached out from the widely used plastics.
KW - Bisphenol a
KW - Diseases
KW - Genes
KW - Phthalates
KW - Proteins
KW - Toxicogenomics
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U2 - 10.1016/j.gene.2011.11.035
DO - 10.1016/j.gene.2011.11.035
M3 - Article
C2 - 22173104
AN - SCOPUS:84856118761
SN - 0378-1119
VL - 494
SP - 85
EP - 91
JO - Gene
JF - Gene
IS - 1
ER -
