Abstract
2-(Acylmethylene)pyrrolidine derivatives were synthesized via intermolecular decarbonylative Mannich reaction from various methyl ketones and 1-alkyl-1-pyrroliniums, generated in situ from 1-alkylprolines. This approach mimics the biosynthetic pathway and provides a direct access to a series of 2-(acylmethylene)pyrrolidine alkaloids, including hygrine, N-methylruspolinone, dehydrodarlinine, and ruspolinone.
Original language | English |
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Pages (from-to) | 6669-6678 |
Number of pages | 10 |
Journal | Journal of Organic Chemistry |
Volume | 80 |
Issue number | 13 |
DOIs | |
Publication status | Published - 2015 Jul 2 |
ASJC Scopus subject areas
- Organic Chemistry