Bioactivity evaluation of a novel formulated curcumin

Se Chun Liao, Wei Hsiang Hsu, Zi Yi Huang, Kun Lin Chuang, Kuan Ting Lin, Chia Ling Tseng, Tung Hu Tsai, Anh Hoang Dao, Chun Li Su, Chi Ying F. Huang

Research output: Contribution to journalArticle

Abstract

Curcumin has been used as a traditional medicine and/or functional food in several cultures because of its health benefits including anticancer properties. However, poor oral bioavailability of curcumin has limited its oral usage as a food supplement and medical food. Here we formulated curcumin pellets using a solid dispersion technique. The pellets had the advantages of reduced particle size, improved water solubility, and particle porosity. This pellet form led to an improvement in curcumin’s oral bioavailability. Additionally, we used the C-Map and Library of Integrated Network-Based Cellular Signatures (LINCS) Unified Environment (CLUE) gene expression database to determine the potential biological functions of formulated curcumin. The results indicated that, similar to conventional curcumin, the formulated curcumin acted as an NF-κB pathway inhibitor. Moreover, ConsensusPathDB database analysis was used to predict possible targets and it revealed that both forms of curcumin exhibit similar biological functions, including apoptosis. Biochemical characterization revealed that both the forms indeed induced apoptosis of hepatocellular carcinoma (HCC) cell lines. We concluded that the formulated curcumin increases the oral bioavailability in animals, and, as expected, retains characteristics similar to conventional curcumin at the cellular level. Our screening platform using big data not only confirms that both the forms of curcumin have similar mechanisms but also predicts the novel mechanism of the formulated curcumin.

Original languageEnglish
Article number2982
JournalNutrients
Volume11
Issue number12
DOIs
Publication statusPublished - 2019 Dec

Fingerprint

Curcumin
curcumin
mouth
Biological Availability
pellets
bioavailability
apoptosis
medical foods
Databases
Apoptosis
foodways
Functional Food
Porosity
water solubility
Traditional Medicine
Insurance Benefits
hepatoma
Dietary Supplements
traditional medicine
Particle Size

Keywords

  • Aurora kinase A
  • Curcumin
  • Formulated curcumin
  • Hepatocellular carcinoma
  • Pharmacokinetics

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Liao, S. C., Hsu, W. H., Huang, Z. Y., Chuang, K. L., Lin, K. T., Tseng, C. L., ... Huang, C. Y. F. (2019). Bioactivity evaluation of a novel formulated curcumin. Nutrients, 11(12), [2982]. https://doi.org/10.3390/nu11122982

Bioactivity evaluation of a novel formulated curcumin. / Liao, Se Chun; Hsu, Wei Hsiang; Huang, Zi Yi; Chuang, Kun Lin; Lin, Kuan Ting; Tseng, Chia Ling; Tsai, Tung Hu; Dao, Anh Hoang; Su, Chun Li; Huang, Chi Ying F.

In: Nutrients, Vol. 11, No. 12, 2982, 12.2019.

Research output: Contribution to journalArticle

Liao, SC, Hsu, WH, Huang, ZY, Chuang, KL, Lin, KT, Tseng, CL, Tsai, TH, Dao, AH, Su, CL & Huang, CYF 2019, 'Bioactivity evaluation of a novel formulated curcumin', Nutrients, vol. 11, no. 12, 2982. https://doi.org/10.3390/nu11122982
Liao SC, Hsu WH, Huang ZY, Chuang KL, Lin KT, Tseng CL et al. Bioactivity evaluation of a novel formulated curcumin. Nutrients. 2019 Dec;11(12). 2982. https://doi.org/10.3390/nu11122982
Liao, Se Chun ; Hsu, Wei Hsiang ; Huang, Zi Yi ; Chuang, Kun Lin ; Lin, Kuan Ting ; Tseng, Chia Ling ; Tsai, Tung Hu ; Dao, Anh Hoang ; Su, Chun Li ; Huang, Chi Ying F. / Bioactivity evaluation of a novel formulated curcumin. In: Nutrients. 2019 ; Vol. 11, No. 12.
@article{a7807d5128214693af912b94eab51785,
title = "Bioactivity evaluation of a novel formulated curcumin",
abstract = "Curcumin has been used as a traditional medicine and/or functional food in several cultures because of its health benefits including anticancer properties. However, poor oral bioavailability of curcumin has limited its oral usage as a food supplement and medical food. Here we formulated curcumin pellets using a solid dispersion technique. The pellets had the advantages of reduced particle size, improved water solubility, and particle porosity. This pellet form led to an improvement in curcumin’s oral bioavailability. Additionally, we used the C-Map and Library of Integrated Network-Based Cellular Signatures (LINCS) Unified Environment (CLUE) gene expression database to determine the potential biological functions of formulated curcumin. The results indicated that, similar to conventional curcumin, the formulated curcumin acted as an NF-κB pathway inhibitor. Moreover, ConsensusPathDB database analysis was used to predict possible targets and it revealed that both forms of curcumin exhibit similar biological functions, including apoptosis. Biochemical characterization revealed that both the forms indeed induced apoptosis of hepatocellular carcinoma (HCC) cell lines. We concluded that the formulated curcumin increases the oral bioavailability in animals, and, as expected, retains characteristics similar to conventional curcumin at the cellular level. Our screening platform using big data not only confirms that both the forms of curcumin have similar mechanisms but also predicts the novel mechanism of the formulated curcumin.",
keywords = "Aurora kinase A, Curcumin, Formulated curcumin, Hepatocellular carcinoma, Pharmacokinetics",
author = "Liao, {Se Chun} and Hsu, {Wei Hsiang} and Huang, {Zi Yi} and Chuang, {Kun Lin} and Lin, {Kuan Ting} and Tseng, {Chia Ling} and Tsai, {Tung Hu} and Dao, {Anh Hoang} and Su, {Chun Li} and Huang, {Chi Ying F.}",
year = "2019",
month = "12",
doi = "10.3390/nu11122982",
language = "English",
volume = "11",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "12",

}

TY - JOUR

T1 - Bioactivity evaluation of a novel formulated curcumin

AU - Liao, Se Chun

AU - Hsu, Wei Hsiang

AU - Huang, Zi Yi

AU - Chuang, Kun Lin

AU - Lin, Kuan Ting

AU - Tseng, Chia Ling

AU - Tsai, Tung Hu

AU - Dao, Anh Hoang

AU - Su, Chun Li

AU - Huang, Chi Ying F.

PY - 2019/12

Y1 - 2019/12

N2 - Curcumin has been used as a traditional medicine and/or functional food in several cultures because of its health benefits including anticancer properties. However, poor oral bioavailability of curcumin has limited its oral usage as a food supplement and medical food. Here we formulated curcumin pellets using a solid dispersion technique. The pellets had the advantages of reduced particle size, improved water solubility, and particle porosity. This pellet form led to an improvement in curcumin’s oral bioavailability. Additionally, we used the C-Map and Library of Integrated Network-Based Cellular Signatures (LINCS) Unified Environment (CLUE) gene expression database to determine the potential biological functions of formulated curcumin. The results indicated that, similar to conventional curcumin, the formulated curcumin acted as an NF-κB pathway inhibitor. Moreover, ConsensusPathDB database analysis was used to predict possible targets and it revealed that both forms of curcumin exhibit similar biological functions, including apoptosis. Biochemical characterization revealed that both the forms indeed induced apoptosis of hepatocellular carcinoma (HCC) cell lines. We concluded that the formulated curcumin increases the oral bioavailability in animals, and, as expected, retains characteristics similar to conventional curcumin at the cellular level. Our screening platform using big data not only confirms that both the forms of curcumin have similar mechanisms but also predicts the novel mechanism of the formulated curcumin.

AB - Curcumin has been used as a traditional medicine and/or functional food in several cultures because of its health benefits including anticancer properties. However, poor oral bioavailability of curcumin has limited its oral usage as a food supplement and medical food. Here we formulated curcumin pellets using a solid dispersion technique. The pellets had the advantages of reduced particle size, improved water solubility, and particle porosity. This pellet form led to an improvement in curcumin’s oral bioavailability. Additionally, we used the C-Map and Library of Integrated Network-Based Cellular Signatures (LINCS) Unified Environment (CLUE) gene expression database to determine the potential biological functions of formulated curcumin. The results indicated that, similar to conventional curcumin, the formulated curcumin acted as an NF-κB pathway inhibitor. Moreover, ConsensusPathDB database analysis was used to predict possible targets and it revealed that both forms of curcumin exhibit similar biological functions, including apoptosis. Biochemical characterization revealed that both the forms indeed induced apoptosis of hepatocellular carcinoma (HCC) cell lines. We concluded that the formulated curcumin increases the oral bioavailability in animals, and, as expected, retains characteristics similar to conventional curcumin at the cellular level. Our screening platform using big data not only confirms that both the forms of curcumin have similar mechanisms but also predicts the novel mechanism of the formulated curcumin.

KW - Aurora kinase A

KW - Curcumin

KW - Formulated curcumin

KW - Hepatocellular carcinoma

KW - Pharmacokinetics

UR - http://www.scopus.com/inward/record.url?scp=85076370462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076370462&partnerID=8YFLogxK

U2 - 10.3390/nu11122982

DO - 10.3390/nu11122982

M3 - Article

C2 - 31817577

AN - SCOPUS:85076370462

VL - 11

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 12

M1 - 2982

ER -